Title:
Methods for engineered microbial and microbial oil production
Document Type and Number:
Japanese Patent JP6294827
Kind Code:
B2
Abstract:
Some aspects of this invention provide engineered microbes for oil production. Methods for microbe engineering and for use of engineered microbes are also provided herein. In some embodiments, microbes are provided that are engineered to modulate a combination of rate-controlling steps of lipid synthesis, for example, a combination of a step generating metabolites, acetyl-CoA, ATP or NADPH for lipid synthesis (a push step), and a step sequestering a product or an intermediate of a lipid synthesis pathway that mediates feedback inhibition of lipid synthesis (a pull step). Such push-and-pull engineered microbes exhibit greatly enhanced conversion yields and TAG synthesis and storage properties.
Inventors:
Stefano Pros, Gregory
Thailand, Mitchell
Chakra Volty, Sagar
Thailand, Mitchell
Chakra Volty, Sagar
Application Number:
JP2014537306A
Publication Date:
March 14, 2018
Filing Date:
October 19, 2012
Export Citation:
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
International Classes:
C12N1/19; C12N15/09; C12P7/64
Domestic Patent References:
| JP2008501323A | ||||
| JP2008524984A |
Foreign References:
| US20100081178 | ||||
| WO2005118814A2 | ||||
| WO2010075440A1 | ||||
| WO2009073822A2 | ||||
| WO2010025374A2 | ||||
| WO2008147935A2 |
Attorney, Agent or Firm:
Kiyoji Kuzuwa
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