Title:
生体試料中のＴＤＰ−４３を測定する方法及び装置
Document Type and Number:
Japanese Patent JP6961278
Kind Code:
B1
Abstract:
【課題】検出感度が高い、ＴＤＰ−４３の測定方法等の実現。【解決手段】生体試料中のＴＤＰ−４３を測定する方法に関する。当該方法に使用される非捕捉ビーズは、生体試料中のＴＤＰ−４３と、捕捉抗体と、検出抗体との免疫複合体とは結合しない。捕捉ビーズ上に免疫複合体が形成されている。検出抗体及び捕捉抗体の少なくとも一方はＴＤＰ−４３を特異的に認識し、捕捉抗体のエピトープと検出抗体のエピトープとが異なる。【選択図】なし
Inventors:
Tokuda Takahiko
Takebe
Takebe
Application Number:
JP2021038665A
Publication Date:
November 05, 2021
Filing Date:
March 10, 2021
Export Citation:
Assignee:
National Institute for Quantum Science and Technology
International Classes:
G01N33/53; G01N33/543
Domestic Patent References:
| JP2019027952A | 2019-02-21 | |||
| JP2015505665A | 2015-02-26 | |||
| JP2019513752A | 2019-05-30 |
Foreign References:
| WO2017170986A1 | 2017-10-05 |
Other References:
徳田隆彦 他: "脳脊髄液および血液中のTDP-43定量とその臨床的有用性", 最新医学, vol. 65, no. 7, JPN6021019643, July 2010 (2010-07-01), JP, pages 1642 - 1647, ISSN: 0004513780
DENG, H-X ET AL.: "Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia", NATURE, vol. 477, JPN6021019647, 8 September 2011 (2011-09-08), pages 211 - 215, ISSN: 0004513781
SUZUKI, H. ET AL.: "Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs", HUMAN MOLECULAR GENETICS, vol. 24, no. 6, JPN7021001877, 6 November 2014 (2014-11-06), pages 1513 - 1527, ISSN: 0004513782
SERAFIN, V. ET AL.: "Disposable immunoplatforms for the simultaneous determination of biomarkers for neurodegenerative di", ANALYTICAL AND BIOANALYTICAL CHEMISTRY, vol. 413, JPN6021019644, 30 May 2020 (2020-05-30), pages 799 - 811, ISSN: 0004513783
DENG, H-X ET AL.: "Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia", NATURE, vol. 477, JPN6021019647, 8 September 2011 (2011-09-08), pages 211 - 215, ISSN: 0004513781
SUZUKI, H. ET AL.: "Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs", HUMAN MOLECULAR GENETICS, vol. 24, no. 6, JPN7021001877, 6 November 2014 (2014-11-06), pages 1513 - 1527, ISSN: 0004513782
SERAFIN, V. ET AL.: "Disposable immunoplatforms for the simultaneous determination of biomarkers for neurodegenerative di", ANALYTICAL AND BIOANALYTICAL CHEMISTRY, vol. 413, JPN6021019644, 30 May 2020 (2020-05-30), pages 799 - 811, ISSN: 0004513783
Attorney, Agent or Firm:
Harakenzo world patent & trademark
Previous Patent: Transmission board member
Next Patent: Rack for hydroponics planter, hydroponics system and hydroponics method
Next Patent: Rack for hydroponics planter, hydroponics system and hydroponics method