Title:
噴霧乾燥器およびインラインジェットミルを用いる粒子を製造するための方法および装置
Document Type and Number:
Japanese Patent JP2006514879
Kind Code:
A
Abstract:
Methods and apparatus are provided for making particles comprising: (a) spraying an emulsion, solution, or suspension, which comprises a solvent and a bulk material (e.g., a pharmaceutical agent), through an atomizer and into a primary drying chamber, having a drying gas flowing therethrough, to form droplets comprising the solvent and bulk material dispersed in the drying gas; (b) evaporating, in the primary drying chamber, at least a portion of the solvent into the drying gas to solidify the droplets and form particles dispersed in drying gas; and (c) flowing the particles and at least a portion of the drying gas through a jet mill to deagglomerate or grind the particles. By coupling spray drying with "in-line" jet milling, a single step process is created from two separate unit operations, and an additional collection step is advantageously eliminated. The one-step, in-line process has further advantages in time and cost of processing.
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Inventors:
Tickering, Donald E. The Third
Narashinhan, slider
Alt router, david
Kopesky, Paul
Keegan, mark
Strobe, Julie A.
Bernstein, Howard
Narashinhan, slider
Alt router, david
Kopesky, Paul
Keegan, mark
Strobe, Julie A.
Bernstein, Howard
Application Number:
JP2004565053A
Publication Date:
May 18, 2006
Filing Date:
November 20, 2003
Export Citation:
Assignee:
Accusphere, Incorporated
International Classes:
B01J2/04; A61K9/14; A61K9/16; B01D1/18; B02C19/06; F26B3/12; F26B17/10
Attorney, Agent or Firm:
Hidekazu Miyoshi
Masakazu Ito
Masakazu Ito