Title:
LFA-1と結合する分子の特定およびレセプター占拠の決定に有用な方法および分子
Document Type and Number:
Japanese Patent JP2004514422
Kind Code:
A
Abstract:
The present invention relates generally to a method for identifying molecules that bind the R7.1 epitope of LFA-1 or bind LFA-1 such that the R7.1 epitope is modified. The present invention further relates to a method for determining occupancy of the LFA-1 receptor by molecules that bind to the R7.1 epitope or bind LFA-1 such that the R7.1 epitope is modified after administration to a subject. The present invention further relates to molecules useful in the methods of the invention.
Inventors:
Woska Joseph Earl
Magorda Ronald El
Lemu René M
Ross Rain Robert
Riser hanssee
Caviness Gary Oh
Kishimoto Takashi
Magorda Ronald El
Lemu René M
Ross Rain Robert
Riser hanssee
Caviness Gary Oh
Kishimoto Takashi
Application Number:
JP2002519943A
Publication Date:
May 20, 2004
Filing Date:
August 13, 2001
Export Citation:
Assignee:
Boehringer Ingelheim Pharmaceuticals, Inc.
International Classes:
C12Q1/04; G01N33/15; G01N33/53; G01N33/543; G01N33/566; G01N33/58; G01N33/50; (IPC1-7): C12Q1/04; G01N33/15; G01N33/50; G01N33/53; G01N33/566
Attorney, Agent or Firm:
Minoru Nakamura
Fumiaki Otsuka
Sadao Kumakura
Shishido Kaichi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo
Takaki Nishijima
Atsushi Hakoda
Fumiaki Otsuka
Sadao Kumakura
Shishido Kaichi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo
Takaki Nishijima
Atsushi Hakoda