Title:
プロスタグランジンプレカーサーの調製のための方法
Document Type and Number:
Japanese Patent JP4493856
Kind Code:
B2
Abstract:
A propargylic alcohol, enriched in the (R)-enantiomer, has formula (I) wherein R is C1-4 alkoxy, halogen, or C1-4 alkyl optionally substituted by OH or halogen. This may be prepared by the steps of: (a) enantioselective (R)-esterification of the racemic alcohol using an acyl donor and a first enzyme; (b) removal of the unreacted (S)-alcohol; and (c) enantioselective hydrolysis of the (R)-ester, using a second enzyme. The alcohol can be converted to a prostaglandin by known means.
Inventors:
Martin edward fox
Julian Simon Palat
Julian Simon Palat
Application Number:
JP2000611700A
Publication Date:
June 30, 2010
Filing Date:
April 11, 2000
Export Citation:
Assignee:
CHIROTECH TECHNOLOGY LIMITED
International Classes:
C12P41/00; C07C43/20; C07C43/23; C07C405/00; C07F7/18; C12P7/22; C12R1/72; C12R1/785
Foreign References:
| WO1995033845A1 |
Attorney, Agent or Firm:
Aoyama Aoi
Mitsuo Tanaka
Michiko Matsutani
Mitsuo Tanaka
Michiko Matsutani