Title:
METHODS FOR PRODUCING MERCAPTANS BY HYDROGEN-ASSISTED DISULFIDE ENZYME HYDROGENOLYSIS
Document Type and Number:
Japanese Patent JP2020185003
Kind Code:
A
Abstract:
To provide methods for producing mercaptans from disulfides and hydrogen by enzymatic catalysis, in particular, methyl mercaptan from dimethyl disulfide and hydrogen.SOLUTION: Disclosed is a method for preparing a mercaptan of formula R-SH, comprising the steps of: a) preparing a mixture of: 1) a disulfide of formula R-S-S-R'; 2) a catalytic amount of a thiol-containing amino acid or thiol-containing peptide; 3) a catalytic amount of an enzyme that catalyzes reduction of a disulfide link formed between two equivalents of the thiol-containing amino acids or two equivalents of thiol-containing peptides; and 4) a catalytic amount of an enzyme that catalyzes reduction of hydrogen; b) adding hydrogen; c) conducting the enzymatic reaction; d) harvesting mercaptans of the formula R-SH and R'-SH; and e) optionally separating or purifying the mercaptan of the formula R-SH and/or the mercaptan of the formula R'-SH.SELECTED DRAWING: Figure 1
Inventors:
GEORGES FREMY
ARNAUD MASSELIN
HUGO BRASSELET
ARNAUD MASSELIN
HUGO BRASSELET
Application Number:
JP2020121867A
Publication Date:
November 19, 2020
Filing Date:
July 16, 2020
Export Citation:
Assignee:
ARKEMA FRANCE
International Classes:
C12P11/00; C07K5/02; C07K5/08; C12N9/02
Domestic Patent References:
| JPH07304730A | 1995-11-21 | |||
| JPS61247391A | 1986-11-04 |
Foreign References:
| US20050260250A1 | 2005-11-24 |
Attorney, Agent or Firm:
Kawaguchi International Patent Office