Title:
ステロイド-5-エン化合物のステロイド-5-エン-7-オン化合物へのアリル酸化、続くヒドロホウ素化および酸化による、6,7-ジヒドロキシステロイドの生成のための方法およびこの方法の中間体
Document Type and Number:
Japanese Patent JP2004534042
Kind Code:
A
Abstract:
Steroids containing a cyclohexene moiety are efficiently oxidized to the corresponding alpha,beta-unsaturated ketone using copper iodide and t-butyl hydroperoxide. A steroid compound containing the alpha,beta-unsaturated ketone structure is efficiently converted to the corresponding vicinal diol using a hydroborating reagent followed by oxidative workup, e.g., borane followed by sodium perborate. Benzoyl and substituted benzoyls are superior protecting groups for hydroxyl groups present in the compounds.
Inventors:
Burgoyne, David El.
Shen, Yuppin
Ji, Gueijun
Elephant, Yuan Lin
Ramachandran, Kishore
Pashaly Death, Nicholas Dee.
Keller, Eugene W.
Shen, Yuppin
Ji, Gueijun
Elephant, Yuan Lin
Ramachandran, Kishore
Pashaly Death, Nicholas Dee.
Keller, Eugene W.
Application Number:
JP2002591522A
Publication Date:
November 11, 2004
Filing Date:
May 22, 2002
Export Citation:
Assignee:
Infra Gym Pharmaceuticals Limited
International Classes:
A61K31/56; C07B53/00; C07J1/00; C07J11/00; C07J21/00; C07J31/00; C07J41/00; C07J53/00; (IPC1-7): C07J1/00; C07J11/00; C07J21/00; C07J31/00; C07J41/00
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita