Title:
生体材料中の病原体不活性化剤をクエンチするための方法
Document Type and Number:
Japanese Patent JP4643004
Kind Code:
B2
Abstract:
Methods are provided for quenching undesired side reactions of pathogen inactivating compounds in biological materials comprising red blood cells. In a particular embodiment, methods are provided for quenching undesired side reactions of a pathogen inactivating compound that includes a functional group which is, or which is capable of forming, an electrophilic group. In this embodiment, the material is treated with the pathogen inactivating compound and a quencher, wherein the quencher comprises a nucleophilic functional group that is capable of covalently reacting with the electrophilic group. The electrophilic group on the pathogen inactivating compound is preferably a non-radical cationic group. In one embodiment, the pathogen inactivating compound includes a nucleic acid binding ligand and a mustard group, wherein the mustard group is capable of reacting in situ to form the electrophilic group. Preferred quenchers are thiols, such as glutathione. The methods permit inhibition of the modification of red blood cells in red blood cell containing materials during pathogen inactivation.
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Inventors:
Cook, david
Stassin Opoulos, Adonis
Stassin Opoulos, Adonis
Application Number:
JP2000527286A
Publication Date:
March 02, 2011
Filing Date:
July 06, 1998
Export Citation:
Assignee:
Cirrus Corporation
International Classes:
A61K35/14; A01N1/02; A61L2/00; A61M1/36; C12N5/08
Domestic Patent References:
| JP60016930A |
Foreign References:
| WO1996039816A1 | ||||
| WO1996014737A1 | ||||
| WO1996039818A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita