Title:
プロブコールモノエステルによって血漿HDLコレステロールレベルを上昇させ、HDLの機能性を改善するための方法
Document Type and Number:
Japanese Patent JP4334233
Kind Code:
B2
Abstract:
It has been discovered that certain selected probucol monoesters, and their pharmaceutically acceptable salts or prodrugs, are useful for increasing circulating HDL cholesterol. These compounds may also improve HDL functionality by (a) increasing clearance of cholesteryl esters, (b) increasing HDL-particle affinity for hepatic cell surface receptors or (c) increasing the half life of apoAI-HDL.
Inventors:
Li Yushi Miyun, Jeira
Saxena, Udai
Sandel, Cynthia El
Sikorsky, The A's A
Saxena, Udai
Sandel, Cynthia El
Sikorsky, The A's A
Application Number:
JP2002584902A
Publication Date:
September 30, 2009
Filing Date:
April 11, 2002
Export Citation:
Assignee:
Aserodynics Incorporated
International Classes:
A61K31/235; A61K45/00; A61K31/05; A61K31/10; A61K31/138; A61K31/198; A61K31/216; A61K31/22; A61K31/225; A61K31/255; A61K31/275; A61K31/40; A61K31/4184; A61K31/4422; A61K31/4706; A61K31/472; A61K31/502; A61K31/506; A61K31/517; A61K31/55; A61K31/554; A61K31/575; A61K45/06; A61P3/06; A61P9/10; C07C323/20; C07C323/21
Foreign References:
| WO1998051289A1 | ||||
| WO1998051662A1 | ||||
| WO2000028332A1 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
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