Title:
レチノイドの毒性を減少するための方法
Document Type and Number:
Japanese Patent JP4772663
Kind Code:
B2
Abstract:
A method of minimizing or reducing the toxicity of a retinoid having a free carboxyl group is described. The method comprises the step of esterifying the carboxyl group of the retinoid with a highly sterically hindered compound, which is preferably an alcohol. The resulting retinoid esters are rendered much less toxic than the starting or parent retinoid. This process provides a retinoid ester analog of reduced toxicity so that it may be administered orally with minimal side effects and with a much greater therapeutic window.
Inventors:
Deluca, Hector Ef
Krugetto-Dahme, Margaret
Highland, Margaret A
Krugetto-Dahme, Margaret
Highland, Margaret A
Application Number:
JP2006501028A
Publication Date:
September 14, 2011
Filing Date:
January 16, 2004
Export Citation:
Assignee:
WISCONSIN ALUMNI RESEARCH FOUNDATION
International Classes:
A61K31/215; A61P17/00; A61P35/00; C07C51/43; C07C403/20; C07J9/00
Domestic Patent References:
| JPS51110551A | 1976-09-30 | |||
| JPH0912538A | 1997-01-14 | |||
| JPH0525123A | 1993-02-02 | |||
| JPH01156921A | 1989-06-20 | |||
| JPS5675424A | 1981-06-22 | |||
| JPS5076048A | 1975-06-21 | |||
| JPS5076047A | 1975-06-21 |
Foreign References:
| WO1998006390A1 | 1998-02-19 |
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri