METHODS AND SYSTEMS FOR PHARMACOGENOMICS TREATMENT OF CARDIOVASCULAR CONDITIONS

Title:

METHODS AND SYSTEMS FOR PHARMACOGENOMICS TREATMENT OF CARDIOVASCULAR CONDITIONS

Document Type and Number:

Japanese Patent JP2014040418

Kind Code:

A

Abstract:

To provide methods and systems for using rostafuroxin (17β-(3-furyl)-5β-androstane-3β,14β,17α-triol) for a carrier of a genetic variation in treatment or prevention of a cardiovascular condition.

Provided is rostafuroxin for use in treatment or prevention of a cardiovascular condition in an individual, where the individual has been selected to be a carrier of at least one polymorphism selected from the group consisting of rs2345088, rs16877182, rs16893522, rs2461911, rs5013093, and rs12513375 and/or of a genetic variation in linkage disequilibrium therewith.

Inventors:

BIANCHI GIUSEPPE
FERRARI PATRIZIA
FABIO MACCIARDI

Application Number:

JP2013168314A

Publication Date:

March 06, 2014

Filing Date:

August 13, 2013

Export Citation:

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Assignee:

ROSTAQUO SPA

International Classes:

A61K31/58; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P9/12; A61P9/14; A61P13/02; A61P25/18; A61P25/28; C12N15/09; C12Q1/68

Foreign References:

WO2007060206A2

2007-05-31

Other References:

JPN6012055063; Ａｍ．　Ｊ．　Ｐｈｙｓｉｏｌ．　Ｒｅｇｕｌ．　Ｉｎｔｅｇｒ．　Ｃｏｍｐ．　Ｐｈｙｓｉｏｌ．Ｖｏｌ．２９０　Ｎｏ．３, 2006, ｐｐ．Ｒ５２９-Ｒ５３５
JPN6012055064; ＰｈａｒｍａｃｏｇｅｎｏｍｉｃｓＶｏｌ．６　Ｎｏ．７, 2005, ｐｐ．７５５-７７５
JPN6012055065; ＰｈａｒｍａｃｏｇｅｎｏｍｉｃｓＶｏｌ．８　Ｎｏ．５, 2007, ｐｐ．４６５-４７２
JPN6012055066; Ｃｅｌｌ．　Ｍｏｌ．　Ｂｉｏｌ．Ｖｏｌ．５２　Ｎｏ．８, 2006, ｐｐ．１５-１８
JPN6012055063; Ａｍ．　Ｊ．　Ｐｈｙｓｉｏｌ．　Ｒｅｇｕｌ．　Ｉｎｔｅｇｒ．　Ｃｏｍｐ．　Ｐｈｙｓｉｏｌ．Ｖｏｌ．２９０　Ｎｏ．３, 2006, ｐｐ．Ｒ５２９-Ｒ５３５
JPN6012055064; ＰｈａｒｍａｃｏｇｅｎｏｍｉｃｓＶｏｌ．６　Ｎｏ．７, 2005, ｐｐ．７５５-７７５
JPN6012055065; ＰｈａｒｍａｃｏｇｅｎｏｍｉｃｓＶｏｌ．８　Ｎｏ．５, 2007, ｐｐ．４６５-４７２
JPN6012055066; Ｃｅｌｌ．　Ｍｏｌ．　Ｂｉｏｌ．Ｖｏｌ．５２　Ｎｏ．８, 2006, ｐｐ．１５-１８

Attorney, Agent or Firm:

Mitsuo Tanaka
Hiroshi Yamazaki
Kenji Tomita

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