Title:
コルヒチン誘導体の方法と使用
Document Type and Number:
Japanese Patent JP2022511214
Kind Code:
A
Abstract:
炎症の治療のためのコルヒチン誘導体、方法及びその使用。特定の実施形態において、コルヒチン誘導体は、式Ｉの化合物である。（Ｉ）JPEG2022511214000070.jpg8779
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Inventors:
Tujinsky, Jack
Fernandez, Maria
Fernandez, Maria
Application Number:
JP2020573412A
Publication Date:
January 31, 2022
Filing Date:
June 28, 2019
Export Citation:
Assignee:
Alberta Health Services
International Classes:
C07C321/22; A61K9/08; A61K31/167; A61K31/27; A61K45/00; A61P9/10; A61P19/06; A61P29/00; A61P37/06; A61P43/00; C07C233/32; C07C237/22
Domestic Patent References:
| JPH1121277A | 1999-01-26 | |||
| JP2013502441A | 2013-01-24 |
Foreign References:
| US3997506A | 1976-12-14 |
Other References:
SUGIO, K. ET AL: "Separation of tubulin-binding and anti-inflammatory activity in colchicine analogs and congeners", LIFE SCIENCES, vol. 40(1), JPN6023020206, 1987, pages 35 - 39, ISSN: 0005062019
"Cytotoxicity of colchicine derivatives in primary cultures of human hepatocytes", BIOMEDICAL PAPERS, vol. 151(1), JPN6023020207, 2007, pages 47 - 52, ISSN: 0005062020
BEN-CHETRIT, E. ET AL: "Mechanism of the anti-inflammatory effect of colchicine in rheumatic diseases: a possible new outloo", RHEUMATOLOGY (OXFORD, UNITED KINGDOM), vol. 45(3), JPN6023020208, 2006, pages 274 - 282, ISSN: 0005062021
CHIA, E. W. ET AL: "Colchicine suppresses neutrophil superoxide production in a murine model of gouty arthritis: a ratio", BRITISH JOURNAL OF PHARMACOLOGY, vol. 153, JPN6023020209, 2008, pages 1288 - 1295, XP055572571, ISSN: 0005062022, DOI: 10.1038/bjp.2008.20
REZAEI, D. ET AL: "Screening Anti-Cancer Drugs against Tubulin using Catch-and-Release Electrospray Ionization Mass Spe", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, vol. 27(5), JPN6023020205, 2016, pages 876 - 885, ISSN: 0005062023
"Cytotoxicity of colchicine derivatives in primary cultures of human hepatocytes", BIOMEDICAL PAPERS, vol. 151(1), JPN6023020207, 2007, pages 47 - 52, ISSN: 0005062020
BEN-CHETRIT, E. ET AL: "Mechanism of the anti-inflammatory effect of colchicine in rheumatic diseases: a possible new outloo", RHEUMATOLOGY (OXFORD, UNITED KINGDOM), vol. 45(3), JPN6023020208, 2006, pages 274 - 282, ISSN: 0005062021
CHIA, E. W. ET AL: "Colchicine suppresses neutrophil superoxide production in a murine model of gouty arthritis: a ratio", BRITISH JOURNAL OF PHARMACOLOGY, vol. 153, JPN6023020209, 2008, pages 1288 - 1295, XP055572571, ISSN: 0005062022, DOI: 10.1038/bjp.2008.20
REZAEI, D. ET AL: "Screening Anti-Cancer Drugs against Tubulin using Catch-and-Release Electrospray Ionization Mass Spe", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, vol. 27(5), JPN6023020205, 2016, pages 876 - 885, ISSN: 0005062023
Attorney, Agent or Firm:
Asamura patent office