Title:
METHOTREXATE BONDED TO POLYMER
Document Type and Number:
Japanese Patent JPH02245028
Kind Code:
A
Abstract:
PURPOSE: To obtain therapeutic effect in curing mouse leukemia by using an ester obtd. by reacting methotrexate with a biocompatible water-soluble hydroxylated polymer as the active component.
CONSTITUTION: A z-antitumor drug (methotrexate content; 1-85%) is provided which contains an ester formed by reacting a carboxyl group of methotrexate or its deriv. with a hydroxyl group of a biocompatible water-soluble hydroxylated polymer, such as poly-α,β-(2-hydroxyethyl) D,L-aspartamide (mol. wt.: 2,000-100,000) represented by the formula [wherein (m/n) is (0/1)-(1/0)]. The drug, when given to an L1210 leukemia mouse in a dose of 60 mg/kg-body wt. by a single abdominal dosage, exhibits a macrobiotic effect of at least 125%.
Inventors:
FUUBERUTO BAADAA
MIHIAERU MAAGAASHIYUTEETO
MERUTEN SHIYURINGUMAN
AKUSERU BUARUHI
TOOMASU GURONAU
DEIITAA HOFUMAN
HANSUUPEETAA KUREEMAA
HANSUUHAARARUTO ZETORATSUEKU
MIHIAERU MAAGAASHIYUTEETO
MERUTEN SHIYURINGUMAN
AKUSERU BUARUHI
TOOMASU GURONAU
DEIITAA HOFUMAN
HANSUUPEETAA KUREEMAA
HANSUUHAARARUTO ZETORATSUEKU
Application Number:
JP2862490A
Publication Date:
September 28, 1990
Filing Date:
February 09, 1990
Export Citation:
Assignee:
HOECHST AG
International Classes:
C07D475/04; A61K9/18; A61K31/505; A61K31/785; A61K47/48; A61P35/00; C08G69/48; (IPC1-7): A61K31/785; C07D475/04; C08G69/48
Attorney, Agent or Firm:
Chika Takagi (2 outside)