Title:
METHOTREXATE DERIVATIVE
Document Type and Number:
Japanese Patent JPS63227588
Kind Code:
A
Abstract:
NEW MATERIAL:A compound expressed by formula I [R1 is branched lower alkyl or acyloxy or lower alkyl substituted by formula II (R2 is lower alkyl).
EXAMPLE: Diisopropyl N-[4-[[(2,4-diamino-6-pteridinyl)-methyl]-methylamino]- benzoyl]-L-glutamate.
USE: An antiulcer agent capable of orally administering.
PREPARATION: The aimed compound is obtained by preparing diethyl N-(4- methylaminobenzoyl)-L-glutamate which is an intermediate from L-glutamic acid and 4-methylbenzoic acid, hydrolyzing the intermediate to afford N-(4- methylaminobenzoyl)-L-glutamic acid, reacting the resultant above-mentioned compound with an alkyl halide expressed by the formula X-R1 (X is halogen) and condensing the product with a 2,4-diamino-6-halomethylpteridine.
Inventors:
SAITO TOSHINORI
IWAZAWA HIROYUKI
NAKAJIMA SHOKICHI
FUJITA HIROSHI
IWAZAWA HIROYUKI
NAKAJIMA SHOKICHI
FUJITA HIROSHI
Application Number:
JP5902287A
Publication Date:
September 21, 1988
Filing Date:
March 16, 1987
Export Citation:
Assignee:
MEIJI SEIKA KAISHA
International Classes:
C07D475/08; A61K31/505; A61K31/519; A61P35/00; (IPC1-7): A61K31/505; C07D475/08
Attorney, Agent or Firm:
Hajime Tsukuni