Title:
MICE EXPRESSING HUMANIZED T CELL CO-RECEPTOR
Document Type and Number:
Japanese Patent JP2022121465
Kind Code:
A
Abstract:
To provide mice expressing a humanized T cell co-receptor.SOLUTION: The invention provides genetically modified non-human animals that express chimeric human/non-human T cell co-receptor polypeptides (e.g., CD4, CD8α, CD8β), as well as embryos, cells and tissues comprising the polypeptides. Also provided are constructs for making the genetically modified animals and methods of making the same. In various embodiments, provided herein is a genetically modified non-human animal, comprising a nucleotide sequence encoding a chimeric human/non-human T cell co-receptor polypeptide.SELECTED DRAWING: None
Inventors:
LYNN MACDONALD
KEBBEDE ANTENEH
TU NAXIN
VERA VORONINA
CAGAN GURER
KEBBEDE ANTENEH
TU NAXIN
VERA VORONINA
CAGAN GURER
Application Number:
JP2022094953A
Publication Date:
August 19, 2022
Filing Date:
June 13, 2022
Export Citation:
Assignee:
REGENERON PHARMACEUTICALS INC
International Classes:
A01K67/027; C12N5/10
Foreign References:
| US20070209083A1 | 2007-09-06 |
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Morishita Natsuki