Title:
微小結晶の形成方法および装置
Document Type and Number:
Japanese Patent JP2004530545
Kind Code:
A
Abstract:
Small crystals are made by mixing a solution of a desired substance with an anti-solvent in a fluidic vortex mixer in which the residence time is less than 1 s, for example 10 ms. The liquid within the fluidic vortex mixer ( 12 ) is subjected to high intensity ultrasound from a transducer ( 20, 22 ) in or on the wall of the mixer, or coupled to a pipe supplying liquid to the mixer. The solution very rapidly becomes supersaturated, and the ultrasound can induce a very large number of nuclei for crystal growth. Small crystals, for example less than 5 mum, are formed that may be of a suitable size for use in inhalers.
Inventors:
Bow michael joseph
McCosland Linda Jane
Stirmand John William
McCosland Linda Jane
Stirmand John William
Application Number:
JP2002587069A
Publication Date:
October 07, 2004
Filing Date:
May 02, 2002
Export Citation:
Assignee:
Accentus Public Limited Company
International Classes:
A61K9/14; A61K9/16; A61K31/43; B01D9/00; B01D9/02; B01F5/00; B01F11/02; B01F13/10; C30B7/00; (IPC1-7): B01D9/02; A61K9/14; A61K31/43
Attorney, Agent or Firm:
Sadao Kumakura
Fumiaki Otsuka
Shishido Kaichi
Village shrine Atsuo
Disciple Maru Ken
Ino Sato
Fumiaki Otsuka
Shishido Kaichi
Village shrine Atsuo
Disciple Maru Ken
Ino Sato