Title:
ミクロ流体タンパク質結晶法
Document Type and Number:
Japanese Patent JP2006513857
Kind Code:
A
Abstract:
The use of microfluidic structures enables high throughput screening of protein crystallization. In one embodiment, an integrated combinatoric mixing chip allows for precise metering of reagents to rapidly create a large number of potential crystallization conditions, with possible crystal formations observed on chip. In an alternative embodiment, the microfluidic structures may be utilized to explore phase space conditions of a particular protein crystallizing agent combination, thereby identifying promising conditions and allowing for subsequent focused attempts to obtain crystal growth.
Inventors:
Hansen, Karl El.
Skoda Lakes, Emmanuel
Somer, Morten
Burger, James M.
Quake, Stephen Earl.
Skoda Lakes, Emmanuel
Somer, Morten
Burger, James M.
Quake, Stephen Earl.
Application Number:
JP2005516928A
Publication Date:
April 27, 2006
Filing Date:
October 01, 2003
Export Citation:
Assignee:
California Institute of Technology
The Regents of The University of California
The Regents of The University of California
International Classes:
B01J19/00; B01D9/02; B01F3/08; B01F5/00; B01F15/04; B01L3/00; B01L9/00; B81B3/00; B81C1/00; C12Q1/68; C30B7/00; C30B29/58; F04B43/04; F15C5/00; F16K99/00; G01N33/53; G01N37/00; B01L3/06; B01L7/00; C40B40/10; G01N13/00
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita