Title:
薬物送達および鑑視適用のためのヒト皮膚の微細穿孔
Document Type and Number:
Japanese Patent JP3899427
Kind Code:
B2
Abstract:
A method of enhancing the permeability of the skin (120, 274) to an analytic for diagnostic purposes or to a drug for therapeutic purposes is described utilizing micro-pore and optionally sonic energy and a chemical enhancer. If selected, the sonic energy may be modulated by means of frequency modulation, amplitude modulation, phase modulation, and/or combinations thereof. Micro-pore is accomplished by (a) ablating the stratum corneum (274) by localized rapid heating of water such that water is vaporized, thus eroding cells; (b) puncturing the stratum corneum (274) which a micro-lancet calibrated to form a micro-pore of up to about 1000 m in diameter (c) ablating the stratum corneum (274) by focusing a tightly focused beam of sonic energy onto the stratum corneum (274); (d) hydraulically puncturing the stratum corneum (274) with a high-pressure jet of fluid to form a micro-pore of up to about 1000 m in diameter; or (e) puncturing the stratum corneum (274) with short pulses of electricity to form a micro-pore of up to about 1000 m in diameter.
Inventors:
Epstein, Jonathan A.
Hatch, Michael Earl.
Young, Defay
Hatch, Michael Earl.
Young, Defay
Application Number:
JP51055297A
Publication Date:
March 28, 2007
Filing Date:
August 29, 1996
Export Citation:
Assignee:
Altair Therapeutics Corporation
International Classes:
A61B5/145; A61B5/00; A61B5/1455; A61B5/1459; A61B5/1473; A61B5/1477; A61B5/1491; A61B5/15; A61B5/151; A61B5/157; A61B10/00; A61K41/00; A61B17/00; A61B17/32; A61B18/20; A61M37/00
Foreign References:
| US4775361 | ||||
| WO1992000106A1 | ||||
| US5165418 | ||||
| WO1994009713A1 | ||||
| US5445611 | ||||
| WO1991012772A1 | ||||
| US5267985 | ||||
| WO1994008655A1 | ||||
| WO1995010223A1 | ||||
| US5344418 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita