MODIFIED ANTIGEN BINDING MOLECULE WITH ALTERED CELL SIGNALING ACTIVITY

Japanese Patent JP2013116120

A

To provide modified antigen binding molecules (ABMs).

In particular embodiments, the invention relates to recombinant monoclonal antibodies or fragments, including chimeric, primatized or humanized antibodies or fragments, having altered ability to modulate cell signaling activity by a target antigen, and/or ability to mediate cross-linking of one or more target antigens. In addition, the invention relates to nucleic acid molecules encoding such modified ABMs, and vectors and host cells comprising such nucleic acid molecules. The invention relates to modified ABMs with modified glycosylation having improved therapeutic properties, for example, including antibodies with increased Fc receptor binding and increased effector function.

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UMANA PABLO
MOESSNER EKKEHARD

JP2013030821A

June 13, 2013

February 20, 2013

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ROCHE GLYCART AG

C12N15/09; A61K39/395; A61P1/02; A61P1/04; A61P1/18; A61P11/00; A61P13/08; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P25/00; A61P35/00; A61P35/02; A61P43/00; C07K16/00; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02

JP2009505650A

2009-02-12

WO2005044859A2	2005-05-19
WO2003068821A2	2003-08-21
WO1999060025A1	1999-11-25

JPN6012048613; 蛋白質　核酸　酵素 Ｖｏｌ．４３，　Ｎｏ．２, 19980201, ｐ．１５９-１６７

Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Ryotaro Takei

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