Title:
改変されたコラーゲンタンパク質およびその用途
Document Type and Number:
Japanese Patent JP7303551
Kind Code:
B2
Abstract:
In order to develop tools and methods useful in a variety of applications, including the research and development of medical treatments which involve the modification of collagen protein and use of the same, the present invention provides a modified collagen protein expressed in a transformed cell and capable of forming collagen fibers outside of the cell, wherein the transformation is performed by introducing, into the cell, polynucleotides coding the modified collagen protein.
Inventors:
Yoshihiro Miwa
Junko Kijima
Junko Kijima
Application Number:
JP2019554262A
Publication Date:
July 05, 2023
Filing Date:
November 14, 2018
Export Citation:
Assignee:
National University Corporation University of Tsukuba
International Classes:
C12N15/62; A01K67/027; C07K14/78; C07K19/00; C12M1/34; C12N5/10; C12N15/12; C12N15/63; C12Q1/02
Domestic Patent References:
| JP2000125872A | ||||
| JP2008067655A | ||||
| JP2010085108A | ||||
| JP2014076026A | ||||
| JP2000506362A |
Foreign References:
| WO2016152882A1 |
Other References:
THEIN, M. C. et al.,"Caenorhabditis elegans Exoskeleton Collagen COL-19: An Adult-Specific Marker for Collagen Modification and Assembly, and the analysis of Organismal Morphology.",DEVELOPMENTAL DYNAMICS,2003年,Vol.226,pp.523-39
MAYE, P. et al.,"Generation and Characterization of Coll10a1-mCherry Reporter Mice.",GENESIS,2011年,Vol.49,pp.410-8
OHANA, R. F. et al.,"HaloTag7: A genetically engineered tag that enhances bacterial expression of soluble proteins and improves protein purification.",PROTEIN EXPRESSION AND PURIFICATION,2009年,Vol.68,pp.110-120,doi: 10.1016/j.pep.2009.05.010
野村純,「伸展運動がヒトにおよぼす影響の解析-分子細胞学的検討-」,千葉大学教育学部研究紀要,2006年,Vol.54,pp.271-274
吉岡秀克,「XI型コラーゲンα1鎖遺伝子:α1鎖の一次構造, その遺伝子発現及び調節機構」,CONNECTIVE TISSUE,1997年,Vol.29,pp.39-47
MAYE, P. et al.,"Generation and Characterization of Coll10a1-mCherry Reporter Mice.",GENESIS,2011年,Vol.49,pp.410-8
OHANA, R. F. et al.,"HaloTag7: A genetically engineered tag that enhances bacterial expression of soluble proteins and improves protein purification.",PROTEIN EXPRESSION AND PURIFICATION,2009年,Vol.68,pp.110-120,doi: 10.1016/j.pep.2009.05.010
野村純,「伸展運動がヒトにおよぼす影響の解析-分子細胞学的検討-」,千葉大学教育学部研究紀要,2006年,Vol.54,pp.271-274
吉岡秀克,「XI型コラーゲンα1鎖遺伝子:α1鎖の一次構造, その遺伝子発現及び調節機構」,CONNECTIVE TISSUE,1997年,Vol.29,pp.39-47
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Hisashi Fujita
Yasuhito Suzuki
Norio Omori
Hisashi Fujita
Yasuhito Suzuki