修飾された脂質化リラキシンＢ鎖ペプチドおよびその治療的使用

Title:

修飾された脂質化リラキシンＢ鎖ペプチドおよびその治療的使用

Document Type and Number:

Japanese Patent JP7295871

Kind Code:

B2

Abstract:

A biologically active single chain Relaxin peptide having the formula Nter-Ac-L-E-G-R-E-K-V-R-A-X19-I-X21-X22-E-G-X25-S-T-F-S-X30-R-A-X33-NH2-Cter, or a salt of solvate thereof, is described.

Inventors:

Olivier Ducro
Stephane Igliano
Sergio Maralto
Claire Minoretti-Ochepie
Elisabetta Bianchi
Lafaille Ingenito
Paola Maggotty
Alessia Santoprete

Application Number:

JP2020541689A

Publication Date:

June 21, 2023

Filing Date:

January 30, 2019

Export Citation:

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Assignee:

SANOFI

International Classes:

C07K14/575; A61K38/22; A61P9/04; A61P9/10; A61P11/00; A61P13/12; A61P17/00; A61P21/00; A61P43/00; C07K19/00

Domestic Patent References:

JP2016531156A

Foreign References:

WO2015157829A1

Other References:

MOHAMMED AKHTER HOSSAIN; ET AL,A SINGLE-CHAIN DERIVATIVE OF THE RELAXIN HORMONE IS A FUNCTIONALLY SELECTIVE AGONIST OF THE G PROTEIN-COUPLED RECEPTOR, RXFP1,CHEMICAL SCIENCE,2016年,VOL:7, NR:6,,PAGE(S):3805 - 3819,http://dx.doi.org/10.1039/C5SC04754D
HOSSAIN M A; ET AL,THE MINIMAL ACTIVE STRUCTURE OF HUMAN RELAXIN-2,JOURNAL OF BIOLOGICAL CHEMISTRY,2011年10月28日,VOL:286, NR:43,,PAGE(S):37555 - 37565,https://doi.org/10.1074/jbc.M111.282194
MOHAMMED AKHTER HOSSAIN; ET AL,SYNTHETIC RELAXINS,CURRENT OPINION IN CHEMICAL BIOLOGY,2014年10月,PAGE(S):47-55,http://dx.doi.org/10.1016/j.cbpa.2014.09.014

Attorney, Agent or Firm:

Junji Yuda
Noriyuki Takebayashi

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