Title:
細胞傷害性が増加した改変ナチュラルキラー細胞及びナチュラルキラー細胞株
Document Type and Number:
Japanese Patent JP6974681
Kind Code:
B2
Abstract:
NK cells and NK cell lines are modified to increase cytotoxicity, wherein the cells and compositions thereof have a use in the treatment of cancer. Production of modified NK cells and NK cell lines is via genetic modification to remove checkpoint inhibitory receptor expression and/or add mutant (variant) TRAIL ligand expression.
Inventors:
O'Dwyer, Michael Amon Peter
Application Number:
JP2018524548A
Publication Date:
December 01, 2021
Filing Date:
July 28, 2016
Export Citation:
Assignee:
NK Therapeutics Limited
International Classes:
C12N5/10; A61K35/17; A61P35/00; A61P35/02; C12N5/0783; C12N15/24; C12N15/26; C12N15/54; C12N15/63
Domestic Patent References:
| JP2008507961A | ||||
| JP2011506592A | ||||
| JP2008505071A |
Other References:
Clin. Cancer Res.,2009年,Vol. 15, No. 6,pp. 2048-2057
Nature Immunology,2014年03月,Vol. 15,pp. 431-438
Cancer Cell,2005年04月,Vol. 27, No. 4,pp. 450-461
Blood,2013年,Vol. 122,Abstract 4499
Exp. Hematol.,2005年,Vol. 33,pp. 1160-1171
Haematologica,2004年,Vol. 89,pp. 338-347
Journal of Cancer,2011年,Vol. 2,pp. 383-385
Nature Immunology,2014年03月,Vol. 15,pp. 431-438
Cancer Cell,2005年04月,Vol. 27, No. 4,pp. 450-461
Blood,2013年,Vol. 122,Abstract 4499
Exp. Hematol.,2005年,Vol. 33,pp. 1160-1171
Haematologica,2004年,Vol. 89,pp. 338-347
Journal of Cancer,2011年,Vol. 2,pp. 383-385
Attorney, Agent or Firm:
Shinichi Sanuki
Takeshi Niwa
Takeshi Niwa