Title:
MODIFIED NUCLEOBASES WITH UNIFORM HYDROGEN-BONDING INTERACTIONS, HOMO- AND HETERO-BASEPAIR BIAS, AND MISMATCH DISCRIMINATION
Document Type and Number:
Japanese Patent JP2023161073
Kind Code:
A
Abstract:
To provide nucleobases, polymer monomers comprising the nucleobases, nucleic acids and analogs thereof comprising the nucleobases, and methods of use thereof.SOLUTION: Described herein are divalent nucleobases that each bind two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid backbone or nucleic acid analog backbone, e.g., in a γ-peptide nucleic acid (γPNA). Also provided are genetic recognition reagents comprising one or more of the divalent nucleobases and a nucleic acid backbone or nucleic acid analog backbone, such as a γPNA backbone. Uses of the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided.SELECTED DRAWING: Figure 1
Inventors:
DANITH H LY
SHIVAJI A THADKE
ASHIF Y SHAIKH
HSIEH WEI-CHE
ALI NAKHI
J DINITHI PERERA
SHIVAJI A THADKE
ASHIF Y SHAIKH
HSIEH WEI-CHE
ALI NAKHI
J DINITHI PERERA
Application Number:
JP2023137843A
Publication Date:
November 06, 2023
Filing Date:
August 28, 2023
Export Citation:
Assignee:
UNIV CARNEGIE MELLON
International Classes:
C12Q1/6876; A61K31/4412; A61K31/513; A61K31/52; A61K31/522; A61P43/00; C07D213/64; C07D239/36; C07D473/30; C07D473/32; C12M1/00; C12M1/34; C12N15/09; C12N15/10; C12N15/11; C12Q1/6806; C12Q1/6813
Attorney, Agent or Firm:
Patent Attorney Corporation Fields International Patent Office