Title:
MODIFIED NUCLEOSIDE FOR TREATMENT OF VIRAL INFECTION AND ABNORMAL CELLULAR PROLIFERATION
Document Type and Number:
Japanese Patent JP2013079250
Kind Code:
A
Abstract:
To provide a pharmaceutical composition for the treatment of viral infections and abnormal cellular proliferation.
The composition is for treating a Flaviviridae (including BVDV and HCV), Orthomyxoviridae (including Influenza A and B) or Paramyxoviridae (including RSV) infection, or conditions related to abnormal cellular proliferation, in a host, including animals, and especially humans, using a nucleoside or its pharmaceutically acceptable salt or prodrug.
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Inventors:
STUYVER LIEVEN
WATANABE KYOICHI
WATANABE KYOICHI
Application Number:
JP2012264126A
Publication Date:
May 02, 2013
Filing Date:
December 03, 2012
Export Citation:
Assignee:
GILEAD PHARMASSET LLC
International Classes:
A61K31/7068; C07D473/18; A61K31/513; A61K31/52; A61K31/522; A61K31/7072; A61K31/7076; A61K31/708; A61P3/12; A61P31/12; A61P31/14; A61P35/00; A61P35/02; A61P43/00; C07D405/04; C07D473/30; C07D473/34; C07H19/048; C07H19/06; C07H19/067; C07H19/10; C07H19/16; C07H19/167; C07H19/20; C07H21/04; C12Q1/68
Domestic Patent References:
| JPH05507267A | 1993-10-21 | |||
| JPS608270A | 1985-01-17 | |||
| JPS6187673A | 1986-05-06 | |||
| JPS6442499A | 1989-02-14 | |||
| JPH07508531A | 1995-09-21 | |||
| JPH0680688A | 1994-03-22 | |||
| JP2004510698A | 2004-04-08 | |||
| JPH11512083A | 1999-10-19 |
Foreign References:
| US4232154A | 1980-11-04 | |||
| US4968690A | 1990-11-06 | |||
| US4975434A | 1990-12-04 | |||
| US5192749A | 1993-03-09 |
Other References:
"Asymmetric Synthesis and Antiviral Activities of l-Carbocyclic 2‘,3‘-Didehydro-2‘,3‘-dideoxy and", J. MED. CHEM., vol. 42(17), JPN6012028120, 1999, pages 3390 - 3399, ISSN: 0002729256
"Synthesis and antiviral activity of carbocyclic 5-substituted uridines and cytidines", NUCLEOSIDES & NUCLEOTIDES, vol. 14(6), JPN6012028124, 1995, pages 1233 - 1249, ISSN: 0002729257
JOURNAL OF MEDICINAL CHEMISTRY, vol. 25(7), JPN6014050402, 1982, pages 806 - 812, ISSN: 0002952076
NUCLEIC ACIDS SYMPOSIUM SERIES, vol. 29, JPN6014050404, 1993, pages 93 - 94, ISSN: 0002952077
CARBOHYDRATE RESEARCH, vol. 328(1), JPN6014050406, 18 August 2000 (2000-08-18), pages 37 - 48, ISSN: 0002952078
ARCHIVES OF VIROLOGY. SUPPLEMENTUM, vol. 7, JPN6014050409, 1993, pages 53 - 62, ISSN: 0002952079
INTERNATIONAL JOURNAL OF STD & AIDS, vol. 4(5), JPN6014050411, 1993, pages 300 - 302, ISSN: 0002952080
"Synthesis and antiviral activity of carbocyclic 5-substituted uridines and cytidines", NUCLEOSIDES & NUCLEOTIDES, vol. 14(6), JPN6012028124, 1995, pages 1233 - 1249, ISSN: 0002729257
JOURNAL OF MEDICINAL CHEMISTRY, vol. 25(7), JPN6014050402, 1982, pages 806 - 812, ISSN: 0002952076
NUCLEIC ACIDS SYMPOSIUM SERIES, vol. 29, JPN6014050404, 1993, pages 93 - 94, ISSN: 0002952077
CARBOHYDRATE RESEARCH, vol. 328(1), JPN6014050406, 18 August 2000 (2000-08-18), pages 37 - 48, ISSN: 0002952078
ARCHIVES OF VIROLOGY. SUPPLEMENTUM, vol. 7, JPN6014050409, 1993, pages 53 - 62, ISSN: 0002952079
INTERNATIONAL JOURNAL OF STD & AIDS, vol. 4(5), JPN6014050411, 1993, pages 300 - 302, ISSN: 0002952080
Attorney, Agent or Firm:
Kawaguchi International Patent Office