Title:
MODIFIED POLYNUCLEOTIDES FOR PRODUCING BIOLOGICS AND PROTEINS ASSOCIATED WITH HUMAN DISEASE
Document Type and Number:
Japanese Patent JP2021192606
Kind Code:
A
Abstract:
To provide therapeutic methods for addressing numberless barriers surrounding effective regulation of intracellular translation and treatment of nucleic acid encoding polypeptide or a fragment thereof.SOLUTION: A polynucleotide comprises (a) an open reading frame encoding a target polypeptide consisting of a nucleotide of modified uridine, cytidine, adenosine, and guanosine, the modified uridine being N1-methyl-pseudouridine; (b) 5'-UTR; (c) at least one 5' cap structure; (d) 3'-UTR; and (e) a 3' tail sequence of a binding nucleoside.SELECTED DRAWING: None
Inventors:
STEPHANE BANCEL
TIRTHA CHAKRABORTY
ANTONIN DE FOUGEROLLES
SAYDA M ELBASHIR
MATTHIAS JOHN
ATANU ROY
SUSAN WHORISKEY
KRISTY M WOOD
PAUL HATALA
JASON P SCHRUM
KENECHI EJEBE
JEFF LYNN ELLSWORTH
JUSTIN GUILD
TIRTHA CHAKRABORTY
ANTONIN DE FOUGEROLLES
SAYDA M ELBASHIR
MATTHIAS JOHN
ATANU ROY
SUSAN WHORISKEY
KRISTY M WOOD
PAUL HATALA
JASON P SCHRUM
KENECHI EJEBE
JEFF LYNN ELLSWORTH
JUSTIN GUILD
Application Number:
JP2021122947A
Publication Date:
December 23, 2021
Filing Date:
July 28, 2021
Export Citation:
Assignee:
MODERNATX INC
International Classes:
A61K31/7088; A61K39/00; A61K39/395; A61K47/54; A61K47/56; A61K47/61; A61K47/64; A61K47/68; A61K48/00; A61M5/142; A61M35/00; A61M37/00; A61P35/00; C12N15/13; C12N15/62; C12P21/00
Attorney, Agent or Firm:
Makoto Onda
Hironobu Onda
Atsushi Honda
Miki Nakamura
Hironobu Onda
Atsushi Honda
Miki Nakamura