PURPOSE: To provide a chemically, modified polypeptide in which antigenicity is eliminated while retaining the physiological activity of polypeptide at a high level, by subjecting amino groups in the molecule of polypeptide with a group contg. a specified polyethylene glycol residue.
CONSTITUTION: Part or the whle of amino groups in the molecule of polypeptide such as uricase, arginase or insulin is substituted with a group of formulaI (wherein R1 is F, Cl, OH or a group which does not react with the polypeptide; the group of formula II is a polyethylene glycol residue having a number- average MW of 5,000W15,000; R2 is alkyl, an arom. group, alkylcarbonyl, arom. carbonyl, alkylaminocarbonyl, arom. amino carbonyl) to produce a modified polypeptide which is an enzyme having a physiological activity effective in the treatment of patients and in which antigenicity is lowered or completely eliminated while retaining highly the physiological activity of the polypeptide.
HIROSE KATSUMI
UNUMA TSUNEO
TOKUNAGA KEIKO
| JPS54119082A | 1979-09-14 | |||
| JPS5599189A | 1980-07-28 |