Title:
修飾された肝炎転写後調節エレメント
Document Type and Number:
Japanese Patent JP6868560
Kind Code:
B2
Abstract:
Provided are polynucleotides containing a modified PRE having a variant X gene that includes one or more stop codons not present in an unmodified, such as wild-type, hepatitis X gene. Also provided are polynucleotides containing a modified PRE having a variant X gene that includes one or more degradation sequences not present in an unmodified, such as wild-type, hepatitis X gene. The modified PRE can be operably linked to a nucleic acid encoding a recombinant protein. Also provided are expression cassettes, viral vectors and cells containing the polynucleotides, and compositions and methods of use thereof.
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Inventors:
Taleen Semifuyu.
Application Number:
JP2017536779A
Publication Date:
May 12, 2021
Filing Date:
January 12, 2016
Export Citation:
Assignee:
Juneau Therapeutics, Inc.
International Classes:
C12N15/51; A61K35/12; A61K35/76; A61K39/395; C12N5/10; C12N7/01; C12N15/13; C12N15/86
Other References:
Gene Therapy,2006年,Vol.13,pp.641-645
J. Virol.,1994年,Vol.68,pp.2026-2030
J. Virol.,1993年,Vol.67,pp.1218-1226
J. Virol.,1994年,Vol.68,pp.2026-2030
J. Virol.,1993年,Vol.67,pp.1218-1226
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto