Title:
改質されたレチノイド化合物及びその使用
Document Type and Number:
Japanese Patent JP4699347
Kind Code:
B2
Abstract:
A method of minimizing or reducing the toxicity of a retinoid having a free carboxyl group and the resulting modified retinoids are described. The method comprises the step of esterifying the carboxyl group of the retinoid with a highly sterically hindered compound, which is preferably a secondary or tertiary alcohol. The resulting retinoid esters are rendered much less toxic than the starting or parent retinoid. This process provides a retinoid ester analog of reduced toxicity so that it may be administered orally with minimal side effects and with a much greater therapeutic window. The modified retinoid compounds are useful in the treatment and prophylaxis of all diseases and disorders where retinoid compounds have been shown effective.
Inventors:
Deluca, Hector Ef
Krugetto-Dahme, Margaret
Goulgari, Smithra
Krugetto-Dahme, Margaret
Goulgari, Smithra
Application Number:
JP2006501027A
Publication Date:
June 08, 2011
Filing Date:
January 16, 2004
Export Citation:
Assignee:
WISCONSIN ALUMNI RESEARCH FOUNDATION
International Classes:
C07C403/20; A61K8/67; A61K31/203; A61K31/215; A61K31/575; A61P17/00; A61P17/06; A61P17/10; A61P35/00; A61P35/02; A61Q19/00; A61Q19/08; C07C69/76; C07J9/00
Domestic Patent References:
| JP9012538A | ||||
| JP5505401A | ||||
| JP5025123A | ||||
| JP1156921A | ||||
| JP56075424A | ||||
| JP3500643A | ||||
| JP50076048A | ||||
| JP50076047A | ||||
| JP5502243A | ||||
| JP51110551A |
Foreign References:
| WO1998006390A1 |
Other References:
European Journal of Pharmaceutical Sciences,1995年,3(2),p.71-76
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri