MODIFIED RHODOMYCIN AND PREPARATION THEREOF

Title:

MODIFIED RHODOMYCIN AND PREPARATION THEREOF

Document Type and Number:

Japanese Patent JPH0256444

Kind Code:

A

Abstract:

NEW MATERIAL: A compound of formula I [wherein R1 is an alkyl; R2 is H, a trialkylsilyl protective group, acetyl, etc.; R3 is H, phenylboric acid, PhB=; R4 is H, a trialkylsikyl protective group, glycosyl of formula II (wherein R5 is OH, acetoxy, amino, etc.; R6 is H, OH, etc.)].

EXAMPLE: 7,10-Bis-O-(trimethylsilyl)-β-rhodomycin.

USE: A tumor therapeutic drug.

PREPARATION: For example, β-rhodomycinone of formula I wherein R1 to R4 are each H is reacted with a trialkylsilyl chloride to obtain a 7,10-bis-O- trialkylsilyl-β-rhodomycinone which is, then, alkylated and further subjected to acid hydrolysis to remove the trialkylsilyl protective group and thus, a compound of formula III which is one of the compounds of the formula I is obtained.

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Inventors:

TSUENETSUKU KOORARU
MANFUREETO GERUKEN
HANSU PEETAA KUREEMAA
PEETAA HERUMENTEIN
KARUSHIYUTEN KUROON
HARIANTO RINOO

Application Number:

JP16718789A

Publication Date:

February 26, 1990

Filing Date:

June 30, 1989

Export Citation:

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Assignee:

BEHRINGWERKE AG

International Classes:

A61K31/65; A61K31/69; A61K31/695; A61K31/70; A61K31/7028; A61K31/7034; A61K31/704; A61P35/00; C07B61/00; C07C45/00; C07C45/65; C07C50/36; C07C67/00; C07C69/63; C07C69/78; C07F5/02; C07F7/18; C07F9/09; C07H15/252; (IPC1-7): A61K31/65; A61K31/69; A61K31/695; A61K31/70; C07B61/00; C07C45/65; C07C50/36; C07C69/63; C07C69/78; C07F5/02; C07F7/18; C07F9/09; C07H15/252

Attorney, Agent or Firm:

Chika Takagi (2 outside)

Next Patent: PRODUCTION OF (R)-ALPHA-METHOXYPHENYLACETIC ACID