MODIFIED TGF-β-SUPERFAMILY PROTEIN

Japanese Patent JP2005320339

A

To provide an improved means for producing in vitro recombinant BMP (bone morphogenic protein) and other TGF-β-family proteins using prokaryotic host and eukaryotic host.

A latent TGF-β-family member fusion protein component for refolding under appropriate refolding conditions is provided, including an N-terminal truncated TGF-β-family protein. The truncated TGF-β-family protein is a fusion protein comprising a TGF-β-family protein C-terminated 7 cysteine domain comprising finger 1 subdomain, finger 2 subdomain and heel subdomain and a breakable modified leader sequence operably joined to the domain and hindering the biological activity associated with the domain, wherein the c-terminated domain is activated in breaking part or the whole of the leader sequence.

JP2019131617	PRODUCING THERAPEUTIC PROTEINS
WO/2014/187269	METHOD FOR PRODUCING DIMERIZED FUSION PROTEIN BY FERMENTATION
WO/1990/010705	PRODUCTION AND PURIFICATION OF RECOMBINANT HUMAN INTERLEUKIN-3 AND MUTEINS THEREOF

OPPERMANN HERMANN
TAI MEI-SHENG
MCCARTNEY JOHN

JP2005156477A

November 17, 2005

May 27, 2005

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STRYKER CORP

C12P21/02; A61K38/00; A61P19/00; A61P21/00; C07K14/47; C07K14/495; C07K19/00; C12N15/09; (IPC1-7): C07K14/495; A61P19/00; A61P21/00; C07K19/00; C12N15/09

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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