Title:
新規の遺伝子スイッチ発現系を介したポリペプチドの発現のモジュレーション
Document Type and Number:
Japanese Patent JP7288401
Kind Code:
B2
Abstract:
Disclosed herein are polynucleotides encoding ligand-inducible gene switch polypeptides, and systems comprising gene switch polypeptides for modulating the expression of a heterologous gene and an interleukin in a host cell. The compositions, methods and systems described herein facilitate ligand dependent expression of polypeptides including but not limited to cytokines and antigen binding polypeptides.
Inventors:
Shah, Rutul Earl.
Reed, Thomas Dee.
Bollinger, Sheryl Gee.
Reed, Thomas Dee.
Bollinger, Sheryl Gee.
Application Number:
JP2019537292A
Publication Date:
June 07, 2023
Filing Date:
January 10, 2018
Export Citation:
Assignee:
Precigen, Inc.
International Classes:
C12N15/63; A61K35/12; A61P35/00; C12N5/10; C12N15/12; C12N15/13; C12N15/19; C12N15/24; C12N15/25; C12N15/26; C12N15/62; C12N15/85; C12N15/867
Domestic Patent References:
| JP2016025858A | ||||
| JP2010540534A |
Other References:
Kim, J. H. et al.,High cleavage efficiency of a 2A peptide derived from porcine teschovirus-1 in human cell lines, zebrafish and mice,PLoS One,2011年,Vol. 6(4):e18556,pp. 1-8
中西 秀之 ほか,トランスポゾンに基づく持続発現型ベクターの開発と治療応用,YAKUGAKU ZASSHI,2009年,Vol. 129(12),pp. 1433-1443
Uchibori, R. et al., Activation signals from CD19-CAR permit NFAT-controlled inducible expression of transgenes in PBMCS,Molecular Therapy,2015年,Vol. 23, SUPPL. 1,p. S89
Hurton, L. V. et al.,Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells,Proc. Natl. Acad. Sci. U S A.,2016年,Vol. 113(48),pp. E7788-E7797
中西 秀之 ほか,トランスポゾンに基づく持続発現型ベクターの開発と治療応用,YAKUGAKU ZASSHI,2009年,Vol. 129(12),pp. 1433-1443
Uchibori, R. et al., Activation signals from CD19-CAR permit NFAT-controlled inducible expression of transgenes in PBMCS,Molecular Therapy,2015年,Vol. 23, SUPPL. 1,p. S89
Hurton, L. V. et al.,Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells,Proc. Natl. Acad. Sci. U S A.,2016年,Vol. 113(48),pp. E7788-E7797
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Emiko Nishizawa
Norio Omori
Emiko Nishizawa