PURPOSE: To modulate the number and/or size of organelles by the treatment such an altering the expression of proteins existing in the organelles, thereby modulate the production of secondary metabolites such as of penicillin or cephalosporin.
CONSTITUTION: The production of the secondary metabolites is modulated by treatment with a chemical capable of altering the expression of proteins existing in a organelles, hampering the cell modulation mechanism for the maturation or cleavage of the organelles, or modulating the number and/or size of the organelles; thereby, the number and/or size of the organelles, pref. microbodies can be modulated. In addition, by deletion or alteration of at least one DNA sequence coding for one or more target signals in at least one kind of protein gene either directly or indirectly involved in the production of secondary metabolites, the intracellular localization of the protein(s) can be adjusted.
RUUROFU ARI RANSU BOOBUENBERUF
WARURAABUEN HENRII MIYUURERU
ADORIANUSU YOHANESU FUERUKUREI
