Title:
MOLECULE COUNTING METHOD
Document Type and Number:
Japanese Patent JP3386883
Kind Code:
B2
Abstract:
PURPOSE: To enable the number of molecules to be measured by a simple method in the measurement of mass utilizing specific binding such as the reaction of antigen and antibody.
CONSTITUTION: A monomolecular film 11 including carrier molecules 2 (antibody molecules or the like) specifically bindable to counted object molecules 4 (antigen molecules or the like) is formed, and the carrier molecules 2 and the counted object molecules 4 are bound on one face side of the monomolecular film 11. The corrugation of the monomolecular film 11 on the bound face side of the counted object molecules 4 is then measured using an inter-atomic energy microscope or the like to count the counted object molecules 4. A monomolecular film 21 including carrier molecules 2 (immuno globulin G molecules or the like) is formed adjacently to the substrate monomolecular film 11 including molecules 1 (protein A molecules or the like) bindable to the carrier molecules 2, and the carrier molecules 2 and the counted object molecules 4 are bound on the surface side of the monomolecular film 21.
Inventors:
Masuo Aizawa
Application Number:
JP11748894A
Publication Date:
March 17, 2003
Filing Date:
May 06, 1994
Export Citation:
Assignee:
TDK Co., Ltd.
International Classes:
G01N33/53; G01N33/483; G01N33/543; G01N37/00; G01Q60/24; G01Q80/00; G01Q90/00; (IPC1-7): G01N33/53; G01N33/483; G01N33/543
Domestic Patent References:
| JP5273212A | ||||
| JP523350A |
Attorney, Agent or Firm:
Youichi Ishii
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