Title:
一置換又は多置換の油水両親媒性ヒポクレリン誘導体及びその製造方法と使用
Document Type and Number:
Japanese Patent JP2018536643
Kind Code:
A
Abstract:
本発明は一置換又は多置換の油水両親媒性ヒポクレリン誘導体及びその製造方法と使用を開示する。本発明で製造されたポリグリコール、第四級アンモニウム塩等の基の置換を含む油水両親媒性ヒポクレリン誘導体は、ヒポクレリン母体に比べて、吸収スペクトルが明らかにレッドシフトし且つモル吸光係数が大幅に高まり、光増感条件下で一重項酸素等の反応性酸素種を効率よく発生させ、その親水性及び疎水性を調整して、該誘導体に異なる油水両親媒性を付与するとともに、細胞又は組織との生体適合性を高めることができ、このような油水両親媒性ヒポクレリン誘導体は、さまざまな臨床薬の要件を満たし、各種薬物投与方式に求められる薬物の親水性と親油性の矛盾を解決し、同じ条件では、本発明に係る油水両親媒性ヒポクレリン誘導体光増感剤は、第１世代及び第２世代の市販光増感剤よりも高い腫瘍細胞に対する光線力学的不活性化能力を有する。
Inventors:
One Ponfei
Wu Jacion
Liu Wamin
Gooin
Gua Jae Chao
Zhong Shiree
Zhang Hong Yen
Wu Jacion
Liu Wamin
Gooin
Gua Jae Chao
Zhong Shiree
Zhang Hong Yen
Application Number:
JP2018521084A
Publication Date:
December 13, 2018
Filing Date:
October 21, 2016
Export Citation:
Assignee:
Technical Institute of Physics and Chemistry of the Chinese Academy of Sciences
International Classes:
C07C225/32; A61K31/136; A61K31/14; A61K31/16; A61K31/215; A61K31/25; A61K31/255; A61K31/4402; A61K31/4425; A61K31/4468; A61K31/498; A61K31/4995; A61K31/5415; A61K31/542; A61K35/74; A61K41/00; A61P9/00; A61P17/00; A61P17/06; A61P19/02; A61P27/02; A61P29/00; A61P35/00; C07C221/00; C07C227/18; C07C229/18; C07C231/12; C07C237/08; C07C239/14; C07C241/02; C07C243/22; C07C249/02; C07C249/08; C07C249/16; C07C251/18; C07C251/38; C07C251/80; C07C303/30; C07C309/69; C07C319/20; C07C323/25; C07C323/45; C07D211/58; C07D213/36; C07D241/38; C07D279/14; C07D487/08; C07D513/04; C07D513/16
Domestic Patent References:
| JP2009505968A | 2009-02-12 |
Foreign References:
| WO2013020204A1 | 2013-02-14 | |||
| CN1266061A | 2000-09-13 |
Other References:
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HONGYING YANG,TAO, ET AL.: "A novel photosensitizer, 2-butylamino-2-demethoxy-hypocrellin B (2-BA-2-DMHB) - its photodynamic eff", BIOCHIMICA ET BIOPHYSICA ACTA, vol. Vol.1540(1), JPN6019020772, 2001, pages 22 - 31, ISSN: 0004258131
ZHANG Y, ET AL.: "Novel surfactant-like hypocrellin derivatives to achieve simultaneous drug delivery in blood plasma", PHOTOCHEMISTRY AND PHOTOBIOLOGY, vol. Vol.86(3), JPN6019020773, 2010, pages 667 - 672, ISSN: 0004258132
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Attorney, Agent or Firm:
Kaji/Suhara Patent Office