Title:
MONO OR POLYENECARBOXILIC ACID DERIVATIVE
Document Type and Number:
Japanese Patent JP3826182
Kind Code:
B2
Abstract:
PURPOSE: To obtain the subject new compound having agonist action on RXR and useful as an immunosuppressive agent in organ transplantation, a preventing and treating agent, etc., of autoimmune diseases (e.g. psoriasis or chronic rheumatism) and malignant neoplasm [e.g. acute (pre)myeloleukemia{9147/28}.
CONSTITUTION: This compound is expressed by the formula Z-(CR3=CR2)n- COOR1 (R1 is H or a carboxyl-protecting group; R2 and R3 are each H, a halogen, a (branched)lower alkyl, etc.; Z is a group of formula I {A, B and D are each C, N, S, O, etc.; X1 and Y1 are each H, a group, of the formula NR4R5 [R4 and R5 are each H, a lower alkyl, etc.] or X1 and Y1 may form an (un)saturated ring which may contain O, S and N together with binding C}, e.g. a group of formula II [Ra, Rb, Rc and Rd are each H, a (branched)lower alkyl, a (branched)lower alkoxy, etc.; (m) is 0 or 1]; (n) is 1-3} or its salt, e.g. ethyl (E)-3-[1-(1-methylethyl)-1,2,3,4-tetrahydroquinolin-6-yl]-2-butenoate.
Inventors:
Shigeki Hibi
Koichi Kikuchi
Hiroyuki Yoshimura
Mitsuo Nagai
Katsuya Tagami
Shinya Abe
Hishinuma Uharu
Junichi Nagakawa
Noriyuki Miyamoto
Flying Takayuki
Ogasawara Aichi
Azuma Seiko
Kenji Tai
Yamanaka Dyuji
Makoto Asada
Koichi Kikuchi
Hiroyuki Yoshimura
Mitsuo Nagai
Katsuya Tagami
Shinya Abe
Hishinuma Uharu
Junichi Nagakawa
Noriyuki Miyamoto
Flying Takayuki
Ogasawara Aichi
Azuma Seiko
Kenji Tai
Yamanaka Dyuji
Makoto Asada
Application Number:
JP28016595A
Publication Date:
September 27, 2006
Filing Date:
October 27, 1995
Export Citation:
Assignee:
Eisai R & D Management Co., Ltd.
International Classes:
C07D209/04; C07D215/14; A61K31/40; A61K31/403; A61K31/404; A61K31/415; A61K31/42; A61K31/435; A61K31/44; A61K31/4418; A61K31/443; A61K31/47; A61K31/495; A61K31/496; A61K31/535; A61K31/5377; A61K31/55; A61P1/16; A61P11/00; A61P17/00; A61P17/06; A61P29/00; A61P35/00; A61P35/02; A61P37/00; A61P37/06; A61P37/08; A61P43/00; C07C51/353; C07C57/48; C07C317/44; C07C323/62; C07D209/08; C07D213/64; C07D213/79; C07D215/18; C07D223/16; C07D231/12; C07D241/12; C07D241/42; C07D261/08; C07D265/36; C07D405/04; C07D455/04; C07D471/06; C07D495/04; (IPC1-7): C07C57/48; A61K31/40; A61K31/40; A61K31/40; A61K31/40; A61K31/415; A61K31/42; A61K31/435; A61K31/44; A61K31/47; A61K31/495; A61K31/535; A61K31/55; C07C51/353; C07C317/44; C07C323/62; C07D209/08; C07D213/64; C07D213/79; C07D215/14; C07D215/18; C07D223/16; C07D231/12; C07D241/12; C07D241/42; C07D261/08; C07D265/36; C07D405/04; C07D455/04; C07D471/06; C07D495/04
Domestic Patent References:
| JP6009616A | ||||
| JP5078315A | ||||
| JP1316363A | ||||
| JP2268181A |
Foreign References:
| US4977276 | ||||
| US4894386 | ||||
| WO1995018130A1 |
Other References:
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Kihm. Prir. Soedin, (1), pp63-70, 1978
Tetrahedron, Vol.46, No.2, pp335-340, 1990
Collect. Czech. Chem. Commun., Vol.43, No.6, pp1484-1487, 1978
Dopov. Akad. Nauk. Ukr. RSR. ser. B., Vol.32, No.9, pp829-834, 1970
J.C.S. Perkin I, No.13, pp1416-1424, 1973
Bioorg. Med. Chem. Lett., Vol.1, No.2, pp107-110,1991
Khim. Geterotsiki. Soedin., No.5, pp608-612, 1983
SYNTHESIS, No.12, pp1142-1144, 1987
Mol. Immunol., Vol.28, No.6, pp641-654, 1991
Attorney, Agent or Firm:
Kaoru Furuya
Takahiko Mizobe
Shinji Mochida
Yoshitsune Kazumasa
Takahiko Mizobe
Shinji Mochida
Yoshitsune Kazumasa