Title:
オレキシン受容体アンタゴニストとしてのモノアミド誘導体
Document Type and Number:
Japanese Patent JP2010535171
Kind Code:
A
Abstract:
The present invention relates to compounds of formula wherein Ar, R1, R2, R3, R4, R5, n, o, and p are as defined herein or to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. The compounds of formula I can be used for the treatment of sleep disorders, such as sleep apnea, narcolepsy, insomnia, parasomnia, jet lag syndrome, circadian rhythms disorder or sleep disorders associated with neurological diseases.
Inventors:
Kunst, Henner
Nettecofen, Matthias
Pinar, Emmanuel
Roche, Olivier
Rogers-Evans, Mark
Nettecofen, Matthias
Pinar, Emmanuel
Roche, Olivier
Rogers-Evans, Mark
Application Number:
JP2010518625A
Publication Date:
November 18, 2010
Filing Date:
July 24, 2008
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07C233/22; A61K31/167; A61K31/198; A61K31/337; A61K31/341; A61K31/343; A61K31/357; A61K31/36; A61K31/381; A61K31/40; A61K31/416; A61K31/4184; A61K31/428; A61K31/437; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/445; A61K31/519; A61P1/04; A61P3/04; A61P3/10; A61P11/06; A61P15/08; A61P19/02; A61P25/00; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P29/00; A61P37/08; C07C231/02; C07C231/12; C07C233/29; C07C235/38; C07C235/74; C07C237/20; C07C237/22; C07C251/48; C07C253/30; C07C255/58; C07C269/06; C07C271/22; C07C315/04; C07C317/32; C07C319/20; C07C323/62; C07D207/12; C07D211/46; C07D213/56; C07D231/56; C07D235/08; C07D235/26; C07D277/62; C07D305/08; C07D307/52; C07D307/79; C07D317/60; C07D319/20; C07D333/24; C07D405/12; C07D471/04; C07D487/04; C07B53/00
Domestic Patent References:
| JP2001294575A | 2001-10-23 | |||
| JP2004515494A | 2004-05-27 | |||
| JP2003521468A | 2003-07-15 |
Attorney, Agent or Firm:
Hajime Tsukuni
Koshiro Tsukuda
Fusayuki Saito
Koshiro Tsukuda
Fusayuki Saito