Title:
ヒトタンパク質Mcm3に対するモノクローナル抗体、その製造方法、およびその使用
Document Type and Number:
Japanese Patent JP4980516
Kind Code:
B2
Abstract:
The present invention relates to monoclonal antibodies against the human Mcm3 protein, hybridoma cell lines that produce such antibodies, procedures for the production and their use, pharmaceutical compositions comprising a monoclonal antibody according to the present invention, their use for the prevention and treating of certain diseases as well as methods relating to the prevention and treatment of diseases associated with Mcm3 expression. Monoclonal antibodies according to the invention detect and bind human Mcm3 monospecifically both in immunohistological and immunobiochemical detection systems. The process for the production of these monoclonal antibodies comprises an initial screening of excess hybridoma supernatant with immunobiochemical methods followed by a second screening of positive hybridoma by means of an immunohistochemical method.
Inventors:
Gerdes, Johannes
Scholzen, Thomas
Endor, elmer
Wolenberg, Claudia
Balon-Roua, Bettina
Hahn, Marguerite
Prila, Patricia
Zutvinski, Johanna
Knippers, Rolf
Scholzen, Thomas
Endor, elmer
Wolenberg, Claudia
Balon-Roua, Bettina
Hahn, Marguerite
Prila, Patricia
Zutvinski, Johanna
Knippers, Rolf
Application Number:
JP2000609452A
Publication Date:
July 18, 2012
Filing Date:
March 31, 2000
Export Citation:
Assignee:
Dako Denmark A/S
International Classes:
A61K39/395; C07K16/18; A61P17/02; G01N33/53; A61P29/00; A61P35/00; A61P37/06; A61P37/08; A61P43/00; C07K1/22; C07K1/32; C07K16/14; C12N5/10; C12N5/16; C12N5/18; C12N5/20; C12P21/08; G01N33/574; G01N33/577; C12R1/91
Other References:
Journal of Cell Science,1995年,Vol.108,p.1381-1389
Genes to Cells,1997年,Vol.2,p.381-399
Genes to Cells,1997年,Vol.2,p.381-399
Attorney, Agent or Firm:
Yoshinori Hosoda