Title:
メディトープ（Ｍｅｄｉｔｏｐｅ）のためのモノクローナル抗体フレームワーク結合インターフェース、メディトープ送達系、およびその使用法
Document Type and Number:
Japanese Patent JP7403509
Kind Code:
B2
Abstract:
An antibody framework binding interface for the cyclic meditopes C-QFDLSTRRLK-C (cQFD; SEQ ID NO:1) and C-QYNLSSRALK-C (cQYN; SEQ ID NO:2) and methods for their use are provided herein. In one embodiment, a binding interface is formed by a framework region, and not a complementarity determining region (CDR), of an antibody or functional fragment thereof. In another embodiment, a therapeutic human or humanized antibody has one or more human framework residues replaced with one or more corresponding murine residues such that a meditope having the sequence cQFD or cQYN stably binds the one or more human framework residues.
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Inventors:
Williams, John Sea.
Donaldson, Joshua, Michael
Horn, david, a
Ma, Yuelon
The, Cindy
Bizmek, Christoph
Avery, Kendra, Nicole
Donaldson, Joshua, Michael
Horn, david, a
Ma, Yuelon
The, Cindy
Bizmek, Christoph
Avery, Kendra, Nicole
Application Number:
JP2021146593A
Publication Date:
December 22, 2023
Filing Date:
September 09, 2021
Export Citation:
Assignee:
City of Hope
International Classes:
C07K2/00; C07K1/22; C07K7/08; C07K16/00; G01N33/53
Other References:
J. Natl. Cancer Inst.,2005年,Vol.97, No.22,pp.1663-1670
Proc. Natl. Acad. Sci. U.S.A.,2000年,Vol.97, No.10,pp.5399-5404
Structure,2001年,Vol.9,pp.679-687
Proc. Natl. Acad. Sci. U.S.A.,2000年,Vol.97, No.10,pp.5399-5404
Structure,2001年,Vol.9,pp.679-687
Attorney, Agent or Firm:
Seiji Ohno
Yuko Matsutoya
Shinsuke Umeda
Yuko Matsutoya
Shinsuke Umeda