Title:
リガンドのRAGEとの相互作用を阻害する単環式および二環式アゾール誘導体
Document Type and Number:
Japanese Patent JP4481011
Kind Code:
B2
Abstract:
This invention provides methods of preparation of one compound. The compound prepared according to the invention is useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, ²-amyloid and amphoterin, and for the management, treatment, control or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis.
Inventors:
Mujari, Adnan Em. Em.
Andrews, Robert Sea.
Gopara Swami, Ramesh
Hari, Anisa
Avoir, Kashi
Kabaja, Gassan
Guo, Xiao-Chuan
Gupta, spanner
Jones, David Earl.
Chen, Shin
Andrews, Robert Sea.
Gopara Swami, Ramesh
Hari, Anisa
Avoir, Kashi
Kabaja, Gassan
Guo, Xiao-Chuan
Gupta, spanner
Jones, David Earl.
Chen, Shin
Application Number:
JP2003574195A
Publication Date:
June 16, 2010
Filing Date:
March 05, 2003
Export Citation:
Assignee:
TRANSTECH PHARMA,INC.
International Classes:
C07D233/64; A61K9/12; A61K31/4164; A61K31/4178; A61K31/4184; A61K31/42; A61K31/4439; A61K31/454; A61K31/4725; A61K31/496; A61K45/00; A61P3/10; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P15/10; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P43/00; C07D233/54; C07D235/08; C07D235/12; C07D235/14; C07D235/18; C07D235/30; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/12; C07D403/14; C07D405/04; C07D405/12; C07D413/12; C07D453/02; C07D235/10
Domestic Patent References:
| JP6206818A | ||||
| JP5013263B1 |
Foreign References:
| US5358960 | ||||
| US4024271 | ||||
| US3708598 |
Other References:
Eur. J. Med. Chem.,2000年,Vol.35,31-39
J. Med. Chem.,1990年,Vol.33,1688-1697
Il Farmaco,1991年,Vol.46,913-924
J. Med. Chem.,1990年,Vol.33,1688-1697
Il Farmaco,1991年,Vol.46,913-924
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Takumi Terachi
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Takumi Terachi