Title:
MORPHINAN DERIVATIVE 14TH POSITION OF WHICH IS SUBSTITUTED, QUATERNARY AMMONIUM SALT THEREOF, METHOD OF PRODUCING THE SAME AND USE
Document Type and Number:
Japanese Patent JP2009263367
Kind Code:
A
Abstract:
To provide a new morphinan compound that can be used as an analgesic of high activity or an opioid antagonist.
The morphinan compound is represented by formula (Ia) [wherein: R1 is an alkyl group, an arylalkyl group or the like; X is an oxygen atom; R2 is an alkyl group, an arylalkyl group or the like; R3 is a hydrogen or the like; R4 is a hydroxy group, an alkoxy group or the like; and R5 is hydrogen or the like].
Inventors:
SCHMIDHAMMER HELMUT
SPETEA MARIANA
SCHUETZ JOHANNES
GREINER ELISABETH
SCHUELLNER FALKO
SAILER BETTINA
STUEBEGGER KURT
SPETEA MARIANA
SCHUETZ JOHANNES
GREINER ELISABETH
SCHUELLNER FALKO
SAILER BETTINA
STUEBEGGER KURT
Application Number:
JP2009122311A
Publication Date:
November 12, 2009
Filing Date:
May 20, 2009
Export Citation:
Assignee:
ALCASYNN PHARMACEUTICALS GMBH
International Classes:
C07D489/08; A61K31/485; A61P1/00; A61P1/10; A61P3/04; A61P19/02; A61P25/04; A61P25/20; A61P25/32; A61P25/36; A61P29/00; C07D489/00
Domestic Patent References:
| JPS55143971A | 1980-11-10 |
Foreign References:
| DE3412727A1 | 1985-10-17 |
Other References:
JPN6009001105; ＳＣＨＭＩＤＨＡＭＭＥＲ， Ｈ． ｅｔ ａｌ．: Ｈｅｔｅｒｏｃｙｃｌｅｓ Ｖｏｌ．４９, 1998, ｐ．４８９-４９７
JPN6012023862; ＳＣＨＭＩＤＨＡＭＭＥＲ，Ｈ． ｅｔ ａｌ: '３-Ｈｙｄｒｏｘｙ ａｎａｌｏｇｓ ｏｆ ｔｈｅ mu-ｓｅｌｅｃｔｉｖｅ ｏｐｉｏｉｄ ａｎｔａｇｏｎｉｓｔ ｃｙｐｒｏｄｉｍｅ' Ｒｅｇｕｌａｔｏｒｙ Ｐｅｐｔｉｄｅｓ Ｎｏ．Ｓｕｐｐｌ． １, 1994, ｐ．Ｓ３７-Ｓ３８
JPN6009001108; ＳＣＨＭＩＤＨＡＭＭＥＲ， Ｈ． ｅｔ ａｌ．: Ｊ． Ｍｅｄ． Ｃｈｅｍ． Ｖｏｌ．３３／Ｎｏ．４, 1990, ｐ．１２００-１２０６
JPN6009001111; ＳＣＨＭＩＤＨＡＭＭＥＲ， Ｈ． ｅｔ ａｌ．: Ｊ． Ｍｅｄ． Ｃｈｅｍ． Ｖｏｌ．３８／Ｎｏ．１６, 1995, ｐ．３０７１-３０７７
JPN6009001104; ＳＣＨＭＩＤＨＡＭＭＥＲ， Ｈ． ｅｔ ａｌ．: Ｈｅｌｖｅｔｉｃａ Ｃｈｉｍｉｃａ Ａｃｔａ Ｖｏｌ．７２, 1989, ｐ．１２３３-１２４０
JPN6012023863; ＳＣＨＭＩＤＨＡＭＭＥＲ，Ｈ． ｅｔ ａｌ: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｂｉｏｌｏｇｉｃａｌ ｅｖａｌｕａｔｉｏｎ ｏｆ １４-ａｌｋｏｘｙｍｏｒｐｈｉｎａｎｓ． １２． Ａ ｐｈｅｎｅｔｈｙｌ ａｎａｌｏｇ ｏｆ ｔｈｅ mu-ｓｅｌｅｃｔｉ' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ Ｖｏｌ．５， Ｎｏ．１７, 1995, ｐ．１９２３-６
JPN6009001103; 長瀬 博: 最新創薬化学 上巻 第１版第３刷, 20010713, ｐ．３７０-３７１
JPN6012023862; ＳＣＨＭＩＤＨＡＭＭＥＲ，Ｈ． ｅｔ ａｌ: '３-Ｈｙｄｒｏｘｙ ａｎａｌｏｇｓ ｏｆ ｔｈｅ mu-ｓｅｌｅｃｔｉｖｅ ｏｐｉｏｉｄ ａｎｔａｇｏｎｉｓｔ ｃｙｐｒｏｄｉｍｅ' Ｒｅｇｕｌａｔｏｒｙ Ｐｅｐｔｉｄｅｓ Ｎｏ．Ｓｕｐｐｌ． １, 1994, ｐ．Ｓ３７-Ｓ３８
JPN6009001108; ＳＣＨＭＩＤＨＡＭＭＥＲ， Ｈ． ｅｔ ａｌ．: Ｊ． Ｍｅｄ． Ｃｈｅｍ． Ｖｏｌ．３３／Ｎｏ．４, 1990, ｐ．１２００-１２０６
JPN6009001111; ＳＣＨＭＩＤＨＡＭＭＥＲ， Ｈ． ｅｔ ａｌ．: Ｊ． Ｍｅｄ． Ｃｈｅｍ． Ｖｏｌ．３８／Ｎｏ．１６, 1995, ｐ．３０７１-３０７７
JPN6009001104; ＳＣＨＭＩＤＨＡＭＭＥＲ， Ｈ． ｅｔ ａｌ．: Ｈｅｌｖｅｔｉｃａ Ｃｈｉｍｉｃａ Ａｃｔａ Ｖｏｌ．７２, 1989, ｐ．１２３３-１２４０
JPN6012023863; ＳＣＨＭＩＤＨＡＭＭＥＲ，Ｈ． ｅｔ ａｌ: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｂｉｏｌｏｇｉｃａｌ ｅｖａｌｕａｔｉｏｎ ｏｆ １４-ａｌｋｏｘｙｍｏｒｐｈｉｎａｎｓ． １２． Ａ ｐｈｅｎｅｔｈｙｌ ａｎａｌｏｇ ｏｆ ｔｈｅ mu-ｓｅｌｅｃｔｉ' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ Ｖｏｌ．５， Ｎｏ．１７, 1995, ｐ．１９２３-６
JPN6009001103; 長瀬 博: 最新創薬化学 上巻 第１版第３刷, 20010713, ｐ．３７０-３７１
Attorney, Agent or Firm:
Yuichi Yamada
Masakazu Noda
Hideki Okita
Masakazu Noda
Hideki Okita