Title:
MORPHINAN DERIVATIVE CRYSTAL, PRODUCTION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION USING THE SAME
Document Type and Number:
Japanese Patent JP2014214156
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide an X-form crystal of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-furyl) acrylamide]morphinan hydrochloride, a production method thereof, and a pharmaceutical composition.SOLUTION: The X-form crystal of the compound has characteristic diffraction peaks at positions of 2θ of 13.6°, 17.2°, 19.1°, 23.2° and 23.8° ±0.2° in its powder x-ray diffraction pattern. An organic solution that is a C-Cether, a C-Calcohol, a C-Cester or combinations thereof, containing hydrogen chloride, is added into a first solution containing an organic solvent with a morphinan derivative salt dispersed to obtain a second solution. The second solution is concentrated and dried to obtain the X-form crystal of morphinan derivative hydrochloride.
Inventors:
WANG YUAN YI
LI YU KAI
SU YU TING
HUNG CHIA CHEN
YAO CHI HSIANG
LI YU KAI
SU YU TING
HUNG CHIA CHEN
YAO CHI HSIANG
Application Number:
JP2014083016A
Publication Date:
November 17, 2014
Filing Date:
April 14, 2014
Export Citation:
Assignee:
EVERLIGHT CHEM IND CORP
International Classes:
C07D489/02; A61K31/485
Domestic Patent References:
| JP2004107342A | 2004-04-08 | |||
| JP2009542633A | 2009-12-03 |
Foreign References:
| WO2006109671A1 | 2006-10-19 | |||
| WO1993015081A1 | 1993-08-05 | |||
| WO2011115173A1 | 2011-09-22 | |||
| WO2008007766A1 | 2008-01-17 |
Other References:
有機化合物結晶作製ハンドブック −原理とノウハウ−, JPN6011053065, 25 July 2008 (2008-07-25), pages 57 - 84, ISSN: 0003028600
Attorney, Agent or Firm:
Patent business corporation patent firm Sykes
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