Title:
糖尿病の処置のためのマルチ・トランスジェニック・ブタ
Document Type and Number:
Japanese Patent JP6525905
Kind Code:
B2
Abstract:
The present invention provides certain animals, and in particular porcine animals, tissue and cells derived from these, which lack any expression of functional alpha 1,3 galactosyltransferase (aGT) and express one or more additional transgenes which make them suitable donors for pancreatic islet xenotransplantation. Methods of treatment and prevention of diabetes using cells derived from such animals are also provided.
Inventors:
David Ayers
Application Number:
JP2016047895A
Publication Date:
June 05, 2019
Filing Date:
March 11, 2016
Export Citation:
Assignee:
Levi Bicoa, Incorporated
International Classes:
C12N15/877; A01K67/027; A61K9/48; A61K35/39; A61P3/10; C12N5/10
Domestic Patent References:
| JP2007529278A | ||||
| JP2007523631A |
Other References:
Transplant International,2007年,Vol. 20,pp. 107-117
Xenotransplantation,2008年,Vol. 15,pp. 87-90
Comparative Immunology, Microbiology & Infectious Diseases,2009年 3月,Vol. 32,pp. 91-105
Cell,1979年,Vol. 18,pp. 545-558
Science,1985年,Vol. 230,pp. 912-916
Transplant Immunology,2009年 6月,Vol. 21,pp. 57-59
Xenotransplantation,2003年,Vol. 10,pp. 615-621
Immunology Today,2000年,Vol. 21, No. 1,pp. 42-48
Xenotransplantation,2008年,Vol. 15,pp. 87-90
Comparative Immunology, Microbiology & Infectious Diseases,2009年 3月,Vol. 32,pp. 91-105
Cell,1979年,Vol. 18,pp. 545-558
Science,1985年,Vol. 230,pp. 912-916
Transplant Immunology,2009年 6月,Vol. 21,pp. 57-59
Xenotransplantation,2003年,Vol. 10,pp. 615-621
Immunology Today,2000年,Vol. 21, No. 1,pp. 42-48
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita