Title:
５−ブロモ−２−（α−ヒドロキシペンチル）安息香酸ナトリウム塩の複数の異なる結晶型及びそれらの調製方法
Document Type and Number:
Japanese Patent JP6483674
Kind Code:
B2
Abstract:
The present invention discloses 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt in different crystal forms and the preparation methods thereof, and belongs to the field of pharmaceutical chemistry. Said different crystal forms of 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt include: amorphous 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt, crystal form A of 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt, and crystal form B of 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt. The different crystal forms of 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt obtained according to the present invention have better stability and water-solubility than the mixed forms of 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt, thus is advantageous for pharmaceutical use. Moreover, the different crystal forms of 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt possess much better therapeutic effect than 5-bromo-2-(±-hydroxypentyl)benzoic acid potassium salt.
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Inventors:
Chuan Jin Biao
Thorn Chuwan Juin
Thorn Chuwan Juin
Application Number:
JP2016526427A
Publication Date:
March 13, 2019
Filing Date:
July 10, 2014
Export Citation:
Assignee:
Chae Chan Ausan Pharmaceutical Company, Limited
International Classes:
C07C51/09; C07C65/01; C07C51/43
Foreign References:
| CN101402565A |
Other References:
平山令明編,有機化合物結晶作製ハンドブック -原理とノウハウ-,丸善株式会社,2008年 7月25日,p.57-84
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Masaru Nakajima
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Masaru Nakajima