Title:
MULTIPLE-VARIABLE DOSE REGIMEN FOR TREATING TNFα-RELATED DISORDERS
Document Type and Number:
Japanese Patent JP2012046524
Kind Code:
A
Abstract:
To provide dose methods for treating TNFα-related disorders, including Crohn's disease, in which TNFα activity is detrimental.
The multiple-variable dose methods for treating disorders in which TNFα activity is detrimental include: administering to a subject in need thereof at least one induction dose of a TNFα inhibitor so that a threshold level of TNFα inhibitor is achieved within the induction phase; and subsequently administering to the subject at least one treatment dose of the TNFα inhibitor within a treatment phase.
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Inventors:
HOFFMAN REBECCA S
CHARTASH ELLIOT
TAYLOR LORI K
GRANNEMAN GEORGE RICHARD
YAN PHILIP
CHARTASH ELLIOT
TAYLOR LORI K
GRANNEMAN GEORGE RICHARD
YAN PHILIP
Application Number:
JP2011202171A
Publication Date:
March 08, 2012
Filing Date:
September 15, 2011
Export Citation:
Assignee:
ABBOTT BIOTECH LTD
International Classes:
A61K45/00; A61K38/00; A61K39/395; A61P17/06; A61P37/00; A61P43/00; C07K16/24; A61P1/00; A61P1/02; A61P1/16; A61P3/00; A61P3/04; A61P3/10; A61P7/04; A61P7/06; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/02; A61P19/00; A61P19/02; A61P25/00; A61P27/02; A61P29/00; A61P31/00; A61P31/04; A61P31/14; A61P35/00; A61P37/06; A61P37/08; A61P39/00
Foreign References:
| WO2002100330A2 | 2002-12-19 |
Other References:
HANAUER SB, ET AL.: "Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial", LANCET, vol. 359, no. 9317, JPN6011012858, 4 May 2002 (2002-05-04), pages 1541 - 1549, XP004797997, ISSN: 0002557682, DOI: 10.1016/S0140-6736(02)08512-4
GOTTLIEB AB, ET AL.: "Infliximab monotherapy provides rapid and sustained benefit for plaque-type psoriasis", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, vol. 48, no. 6, JPN6011012859, June 2003 (2003-06-01), pages 829 - 835, XP002477491, ISSN: 0002557683, DOI: 10.1067/mjd.2003.307
LORENZ HM: "Technology evaluation: adalimumab, Abbott laboratories", CURRENT OPINION IN MOLECULAR THERAPEUTICS, vol. 4, no. 2, JPN7011000817, April 2002 (2002-04-01), pages 185 - 190, ISSN: 0002557684
竹内勤, ET AL.: "ＴＮＦ阻害による関節リウマチの治療", 日本臨床免疫学会会誌, vol. 27, no. 1, JPN6011012861, February 2004 (2004-02-01), pages 7 - 15, ISSN: 0002557685
CHEN DM, ET AL.: "Adalimumab efficacy and safety in patients with moderate to severe chronic plaque psoriasis: prelimi", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, vol. Vol. 50, No. 3, Suppl. 1, JPN6011012860, March 2004 (2004-03-01), pages 1 - 2, ISSN: 0002557686
FEAGAN BG, ET AL.: "A Comparison of Methotrexate with Placebo for the Maintenance of Remission in Crohn's Disease", NEW ENGLAND JOURNAL OF MEDICINE, vol. 342, no. 22, JPN6011012862, 1 June 2000 (2000-06-01), pages 1627 - 1632, XP055408827, ISSN: 0002557687
GOTTLIEB AB, ET AL.: "Infliximab monotherapy provides rapid and sustained benefit for plaque-type psoriasis", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, vol. 48, no. 6, JPN6011012859, June 2003 (2003-06-01), pages 829 - 835, XP002477491, ISSN: 0002557683, DOI: 10.1067/mjd.2003.307
LORENZ HM: "Technology evaluation: adalimumab, Abbott laboratories", CURRENT OPINION IN MOLECULAR THERAPEUTICS, vol. 4, no. 2, JPN7011000817, April 2002 (2002-04-01), pages 185 - 190, ISSN: 0002557684
竹内勤, ET AL.: "ＴＮＦ阻害による関節リウマチの治療", 日本臨床免疫学会会誌, vol. 27, no. 1, JPN6011012861, February 2004 (2004-02-01), pages 7 - 15, ISSN: 0002557685
CHEN DM, ET AL.: "Adalimumab efficacy and safety in patients with moderate to severe chronic plaque psoriasis: prelimi", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, vol. Vol. 50, No. 3, Suppl. 1, JPN6011012860, March 2004 (2004-03-01), pages 1 - 2, ISSN: 0002557686
FEAGAN BG, ET AL.: "A Comparison of Methotrexate with Placebo for the Maintenance of Remission in Crohn's Disease", NEW ENGLAND JOURNAL OF MEDICINE, vol. 342, no. 22, JPN6011012862, 1 June 2000 (2000-06-01), pages 1627 - 1632, XP055408827, ISSN: 0002557687
Attorney, Agent or Firm:
Yoshio Kawaguchi
Chihiro Watanabe
Katsuma Osaki
Chihiro Watanabe
Katsuma Osaki