Title:
クローディン６を標的とする多重特異性抗原結合分子およびその使用
Document Type and Number:
Japanese Patent JP6971419
Kind Code:
B2
Abstract:
The present disclosure provides multispecific antigen-binding molecules capable of binding to CD3 and CD137 (4-1BB) but not binding to CD3 and CD137 at the same time, and capable of binding to CLDN6. The multispecific antigen-binding molecules of the present disclosure exhibit enhanced T-cell dependent cytotoxicity activity in a CLDN6-dependent manner through binding to the CD3/CD37 and CLDN6. The present invention provides multi-specific antigen-binding molecules and pharmaceutical compositions thereof that can be used for targeting cells expressing CLDN6, for use in immunotherapy for treating various cancers, especially those associated with CLDN6 such as CLDN6-positive cancers.
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Inventors:
Shinya Ishii
Naoki Kimura
Kodama Tatsushi
Naoki Kimura
Kodama Tatsushi
Application Number:
JP2021056457A
Publication Date:
November 24, 2021
Filing Date:
March 30, 2021
Export Citation:
Assignee:
Chugai Pharmaceutical Co., Ltd.
International Classes:
C12N15/13; A61K39/395; A61P35/00; C07K16/28; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/62; C12P21/08
Foreign References:
| WO2019111871A1 | ||||
| WO2014075697A1 | ||||
| WO2019135404A1 |
Attorney, Agent or Firm:
Masao Haruna
Hatsushi Shimizu
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto
Hatsushi Shimizu
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto