Title:
MULTISPECIFIC BINDING MOLECULES TARGETING ABERRANT CELLS
Document Type and Number:
Japanese Patent JP2018046811
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide proteinaceous binding molecules with improved specificity for targeting aberrant cells in autoimmune diseases and cancer, and with reduced risk of undesirable side effects induced by unintentionally targeting normal cells.SOLUTION: The invention provides a proteinaceous molecule comprising at least two different specific binding domains separated by at least one linker for different binding sites, where the proteinaceous molecule comprises a single polypeptide chain, and at least one specific binding domain that specifically binds to MHC1-MAGE peptide complex.SELECTED DRAWING: None
Inventors:
RALPH ALEXANDER WILLEMSEN
JOHAN RENES
JOHAN RENES
Application Number:
JP2017173519A
Publication Date:
March 29, 2018
Filing Date:
September 08, 2017
Export Citation:
Assignee:
APO T BV
International Classes:
C12N15/09; A61K38/16; A61P35/00; A61P37/02; C07K14/475; C07K14/52; C07K14/575; C07K16/18; C07K16/46; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/00; C12P21/08
Foreign References:
| WO2011001152A1 | 2011-01-06 | |||
| WO2000031239A1 | 2000-06-02 |
Other References:
河上裕: "Ｔ細胞により認識されるヒトメラノーマ抗原の単離同定と免疫遺伝子治療への応用", 日本リンパ網内系学会会誌, vol. 37, no. 3, JPN6018039546, 1997, pages 137 - 144, ISSN: 0004077025
J IMMUNOL. 2004 FEB 15;172(4):2232-7, JPN6019027319, ISSN: 0004077026
J IMMUNOL. 2004 FEB 15;172(4):2232-7, JPN6019027319, ISSN: 0004077026
Attorney, Agent or Firm:
Ikeda adult
Junichiro Sakamaki
Masakazu Noda
Kazuhiro Yamaguchi
Junichiro Sakamaki
Masakazu Noda
Kazuhiro Yamaguchi
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