Title:
多価ワクチン組成物
Document Type and Number:
Japanese Patent JP7384667
Kind Code:
B2
Abstract:
Stable, immunogenic combination vaccine(s) comprising a mixture of antigens for prevention and prophylaxis of infections caused by Rotavirus, Poliomyelitis virus, Haemophilus influenzae, Corynebacterium diphtheriae, Clostridium tetani, Bordetella pertussis and Hepatitis B virus. A multivalent combination vaccine comprises i) significantly dose-reduced Salk-IPV or Sabin-IPV (IPV) antigens prepared by methods of formaldehyde inactivation and alum hydroxide adsorption resulting in maximum D-antigen recovery; ii) Injectable heat inactivated Rotavirus antigen(s) providing broad cross-protective immunity among human rotavirus strains; iii) Hib PRP-carrier protein conjugate having improved stability and immunogenicity; iv) whole cell pertussis antigen with improved immunogenicity and stability; and v) Homogenous fractions of Diphtheria and Tetanus toxoids. Such stable and immunogenic vaccine compositions are made by i) individually adsorbing dose reduced IPV, IRV antigens on alum hydroxide and keeping other antigen(s) unadsorbed or adsorbed on alum phosphate, alum hydroxide, or a combination thereof; and ii) using an order of addition of antigens during blending.
Inventors:
Rajiv Malasakant Dere
Sambuhaj Shankar Pisar
Jagdish Kamaraj Zade
Rajendra Narayan Sabal
Ravindra Baprao Kadam
Abhijeet Sanjeev Kumble
Paomin Qian
roger glass
Sambuhaj Shankar Pisar
Jagdish Kamaraj Zade
Rajendra Narayan Sabal
Ravindra Baprao Kadam
Abhijeet Sanjeev Kumble
Paomin Qian
roger glass
Application Number:
JP2019532214A
Publication Date:
November 21, 2023
Filing Date:
August 24, 2017
Export Citation:
Assignee:
Seram Institute of India Private Limited
The United States of America, As Represented by the Secretary, Department of Health and Human Services
The United States of America, As Represented by the Secretary, Department of Health and Human Services
International Classes:
A61K39/295; A61K39/00; A61K39/015; A61K39/02; A61K39/04; A61K39/05; A61K39/07; A61K39/08; A61K39/085; A61K39/09; A61K39/095; A61K39/10; A61K39/102; A61K39/12; A61K39/13; A61K39/15; A61K39/165; A61K39/187; A61K39/20; A61K39/29; A61K39/385; A61K39/39; A61K47/02; A61K47/10; A61K47/64; A61P31/00; A61P31/12
Domestic Patent References:
| JP2008536515A |
Foreign References:
| WO2012093406A2 | ||||
| WO2016063291A1 | ||||
| WO2010132561A2 |
Attorney, Agent or Firm:
Atsushi Aoki
Shinji Mihashi
Junichi Tsuruta
Tomohiro Minamiyama
Youichi Watanabe
Naonori Koda
Shinji Mihashi
Junichi Tsuruta
Tomohiro Minamiyama
Youichi Watanabe
Naonori Koda
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