NEW MATERIAL:A muramyldipeptide derivative of formula I: (X is amino acid, e.g. L-alanin, L-serine, or L-valine; n is an integer 1W6; R1 is H, lower alkyl, carboxyl group, etc.; A1 and A2 are intermediate to higher mycoloyl or 20W60C synthetic higher fatty acid residues which may be branched, one of them may be H).
EXAMPLE: Nα-(N-acetylmuramyl-L-alanyl-D-isoglutaminyl)-Nξ-(6-O-mycomycoloyl- N-acetylmuramyl-L-alanyl-D-isoglutaminyl)-L-lysine.
USE: Medicines capable of preparing uniform suspensions with a phosphoric acid buffer physiological salt solution having improved lipophilic nature, and tumor cell damage activity (closely related to the antitumor activity).
PROCESS: A compound of formula II is condensed with a compound of formula III by the ordinary peptide synthesis to give the objective compound of formula I.
SHIBA TETSUO
AZUMA ICHIROU
KUSUMOTO SHIYOUICHI
NAGASE OSAMU
NICHIMA TSUNEO
| JPS55391A | 1980-01-05 |