Title:
糖尿病の治療用のN-(((((1,3-チアゾール-2-イル)アミノ)カルボニル)フェニル)スルホニル)フェニルアラニン誘導体及び関連化合物
Document Type and Number:
Japanese Patent JP2006524248
Kind Code:
A
Abstract:
The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance or hyperglycemia. These compounds include inhibitors of protein tyrosine phosphatase (PTP-1B) that are useful in the treatment of diabetes and other PTP-1B mediated diseases, such as cancer, neurodegenerative diseases and the like. The compounds of the invention are also useful in pharmaceutical compositions and methods of treating the aforementioned conditions.
Inventors:
Fan Xand, Michael, Shee.
Fan, Haichuan
Fu, Xiao Jin
White House, Darren
Fan, Haichuan
Fu, Xiao Jin
White House, Darren
Application Number:
JP2006510073A
Publication Date:
October 26, 2006
Filing Date:
April 14, 2004
Export Citation:
Assignee:
The Institute for Pharmaceutical Discovery, LRC
International Classes:
C07C311/21; A61K31/19; A61K31/192; A61K31/40; A61K31/415; A61K31/426; A61K31/4406; A61K31/445; A61K31/4965; A61P3/10; A61P43/00; C07D211/34; C07D213/55; C07D215/18; C07D231/06; C07D231/12; C07D239/42; C07D239/78; C07D239/84; C07D277/00; C07D277/20; C07D277/26; C07D277/42; C07D277/46; C07D307/91; C07D417/04; C07D417/12; A61K
Domestic Patent References:
| JP2005508355A | 2005-03-31 | |||
| JP2003509429A | 2003-03-11 | |||
| JP2002114768A | 2002-04-16 |
Foreign References:
| WO2002028844A1 | 2002-04-11 | |||
| WO2001083461A1 | 2001-11-08 |
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio