N- Acyl hydrazone derivative for an alternative T-lymph cell depressant and anti-lymphoid malignant tumor medicine

Japanese Patent JP6139682

B2

The present invention relates to novel N-acylhydrazone derivatives, and more particularly to novel N-acylhydrazone derivatives having selective T cell inhibitory activity and/or anti-lymphoid malignancy activity, stereoisomers thereof, pharmaceutically acceptable salts thereof, the use thereof for preparing pharmaceutical compositions, pharmaceutical compositions containing the same, treatment methods using the compositions, and methods for preparing the novel N-acylhydrazone derivatives.

Cheho Jin
Jewon
Lee Chang Gong
Hanina
Sosugil
Lee Seung-mi
Lee Sung Min

JP2015529676A

May 31, 2017

August 29, 2013

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Chung Kung Dan Pharmaceutical Corporation
Inje University Industry Academic Foundation

C07D209/08; A61K31/404; A61K31/4184; A61K31/433; A61K31/4439; A61K31/454; A61K31/506; A61K31/5377; A61P25/00; A61P29/00; A61P35/02; A61P37/06; C07D209/30; C07D235/08; C07D285/14; C07D401/06; C07D401/12; C07D403/12; C07D405/12; C07D405/14; C07D409/12; C07D409/14

JP2010523579A

Bioorganic & Medicinal Chemistry Letters,2012年,22(10),3571-3574
Misra, Shobha; Satsangi, R. K.; Agarwal, Rajesh; Tiwari, S. S.,Synthesis of 2-substituted phenyl-3-aryloxyacetyl hydrazono methylenyl-indoles as central nervous system active agents,Journal of the Chemical Society of Pakistan,1981年,3(4),199-202

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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